PMID- 16581475
OWN - NLM
STAT- MEDLINE
DCOM- 20060502
LR  - 20161128
IS  - 1097-6795 (Electronic)
IS  - 0894-7317 (Linking)
VI  - 19
IP  - 4
DP  - 2006 Apr
TI  - Relation between flow reserve capacity of penetrating intramyocardial coronary 
      arteries and myocardial fibrosis in hypertension: study using transthoracic 
      Doppler echocardiography.
PG  - 373-8
AB  - OBJECTIVE: The purpose of this study was to compare coronary flow reserve (CFR) 
      capacity of penetrating intramyocardial coronary artery (PICA) using 
      transthoracic Doppler echocardiography and biochemical marker of myocardial 
      fibrosis in hypertension (HTN). METHODS: In 58 patients (male:female ratio = 
      31:27; mean age 47 +/- 9 years) with chest pain and normal coronary angiogram 
      findings, the width of color Doppler signal and peak diastolic velocity of PICA 
      flow were measured in the myocardium just beneath the apical impulse window using 
      transthoracic Doppler echocardiography. PICA-CFR and PICA-width ratio were 
      calculated as the ratio of hyperemic to baseline peak diastolic velocity and as 
      the ratio of hyperemic to baseline width after the adenosine infusion (140 
      mug/kg/min), respectively. Serum carboxy-terminal propeptide of procollagen type 
      I, as a biochemical marker, was measured and patients were divided into 3 groups: 
      19 with HTN and PICA-CFR less than 2.0 (group A); 23 with HTN and PICA-CFR of 2.0 
      or more (group B); and 16 who were normotensive with PICA-CFR of 2.0 or more 
      (group C). RESULTS: Baseline peak diastolic velocity for group A was higher than 
      the other two groups (P < .005 vs groups B and C). PICA-width ratio was higher 
      than the other two groups (P < .005 vs groups B and C). Serum propeptide of type 
      I was 137.1 +/- 16.6 ng/mL in group A, 96.2 +/- 13.7 ng/mL in group B, and 78.8 
      +/- 11.2 ng/mL in group C (P < .0001 vs group B and group C). PICA-CFR was 
      closely related to serum propeptide of type I (P < .001, r = -0.723). CONCLUSION: 
      The impaired PICA-CFR is related to myocardial fibrosis in patients with HTN, 
      chest pain, and normal coronary angiogram results.
FAU - Youn, Ho-Joong
AU  - Youn HJ
AD  - Division of Cardiology, Department of Internal Medicine, College of Medicine, 
      TheCatholic University of Korea, St Mary's Hospital, Youngdungpo-ku, Seoul, 
      Korea. younhj@catholic.ac.kr
FAU - Ihm, Sang-Hyun
AU  - Ihm SH
FAU - Lee, Jong-Min
AU  - Lee JM
FAU - Park, Chul-Soo
AU  - Park CS
FAU - Cho, Eun-Joo
AU  - Cho EJ
FAU - Jung, Hae-Ok
AU  - Jung HO
FAU - Jeon, Hui-Kyung
AU  - Jeon HK
FAU - Oh, Yong-Seog
AU  - Oh YS
FAU - Chung, Wook-Sung
AU  - Chung WS
FAU - Kim, Jae-Hyung
AU  - Kim JH
FAU - Choi, Kyu-Bo
AU  - Choi KB
FAU - Hong, Soon-Jo
AU  - Hong SJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Am Soc Echocardiogr
JT  - Journal of the American Society of Echocardiography : official publication of the 
      American Society of Echocardiography
JID - 8801388
SB  - IM
MH  - Coronary Artery Disease/complications/*diagnostic imaging
MH  - Coronary Circulation
MH  - Coronary Vessels/diagnostic imaging
MH  - Echocardiography, Doppler/*methods
MH  - Endomyocardial Fibrosis/complications/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Hypertension/complications/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Statistics as Topic
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/etiology
EDAT- 2006/04/04 09:00
MHDA- 2006/05/04 09:00
CRDT- 2006/04/04 09:00
PHST- 2005/08/12 00:00 [received]
PHST- 2006/04/04 09:00 [pubmed]
PHST- 2006/05/04 09:00 [medline]
PHST- 2006/04/04 09:00 [entrez]
AID - S0894-7317(05)00995-8 [pii]
AID - 10.1016/j.echo.2005.10.011 [doi]
PST - ppublish
SO  - J Am Soc Echocardiogr. 2006 Apr;19(4):373-8. doi: 10.1016/j.echo.2005.10.011.