PMID- 16584060
OWN - NLM
STAT- MEDLINE
DCOM- 20060425
LR  - 20071115
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 52
IP  - 3-4
DP  - 2006
TI  - Hyperhomocysteinemia--the biochemical link between a weak heart and brittle 
      bones?
PG  - 137-47
AB  - Osteoporosis, chronic heart failure (CHF) and mild to moderate 
      hyperhomocysteinemia (HHCY) can frequently be found in elderly individuals and 
      often occur in the same individual. Due to demographic changes in the number of 
      elderly people the total number of individuals suffering from osteoporosis and/or 
      CHF, and hence the cost to society, will increase dramatically over the next 50 
      years. Thus, prevention of these diseases by identifying and modifying risk 
      factors is a major issue. Recent large population-based prospective studies 
      suggested HHCY as an independent risk factor for CHF and osteoporosis. However, 
      the mechanisms that link HHCY to CHF and osteoporosis are almost unknown. 
      Moreover, until now both diseases have been considered as independent diseases. 
      The finding that heart and bones share a common biochemical risk factor raises 
      the question if there is a biochemical link between these two diseases? This 
      manuscript reviews the existing literature about HHCY and osteoporosis, about 
      HHCY and CHF, and about possible mechanisms that link HHCY to both diseases. 
      Existing data suggest that HHCY could be a useful paradigm with most interesting 
      therapeutic implications, because HCY lowering therapy could favourably influence 
      the course in CHF and osteoporotic patients.
FAU - Herrmann, Markus
AU  - Herrmann M
AD  - Institut fur Klinische Chemie und Laboratoriumsmedizin / Zentrallabor, 
      Universitatsklinikum des Saarlandes, Homburg / Saar, Germany. markusherr@aol.com
FAU - Taban-Shomal, Omid
AU  - Taban-Shomal O
FAU - Muller, Stefanie
AU  - Muller S
FAU - Gunter, Laureen
AU  - Gunter L
FAU - Hubner, Ulrich
AU  - Hubner U
FAU - Bohm, Michael
AU  - Bohm M
FAU - Herrmann, Wolfgang
AU  - Herrmann W
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Heart Failure/*complications/metabolism/pathology
MH  - Humans
MH  - Hyperhomocysteinemia/*complications/metabolism/pathology
MH  - Osteoporosis/*complications/metabolism/pathology
MH  - Risk Factors
RF  - 166
EDAT- 2006/04/06 09:00
MHDA- 2006/04/28 09:00
CRDT- 2006/04/06 09:00
PHST- 2006/04/06 09:00 [pubmed]
PHST- 2006/04/28 09:00 [medline]
PHST- 2006/04/06 09:00 [entrez]
PST - ppublish
SO  - Clin Lab. 2006;52(3-4):137-47.