PMID- 16584112
OWN - NLM
STAT- MEDLINE
DCOM- 20090318
LR  - 20151119
IS  - 1740-2522 (Print)
IS  - 1740-2530 (Electronic)
IS  - 1740-2522 (Linking)
VI  - 12
IP  - 4
DP  - 2005 Dec
TI  - Inhibition of progenitor dendritic cell maturation by plasma from patients with 
      peripartum cardiomyopathy: role in pregnancy-associated heart disease.
PG  - 265-73
AB  - Dendritic cells (DCs) play dual roles in innate and adaptive immunity based on 
      their functional maturity, and both innate and adaptive immune responses have 
      been implicated in myocardial tissue remodeling associated with cardiomyopathies. 
      Peripartum cardiomyopathy (PPCM) is a rare disorder which affects women within 
      one month antepartum to five months postpartum. A high occurrence of PPCM in 
      central Haiti (1 in 300 live births) provided the unique opportunity to study the 
      relationship of immune activation and DC maturation to the etiology of this 
      disorder. Plasma samples from two groups (n = 12) of age- and parity-matched 
      Haitian women with or without evidence of PPCM were tested for levels of 
      biomarkers of cardiac tissue remodeling and immune activation. Significantly 
      elevated levels of GM-CSF, endothelin-1, proBNP and CRP and decreased levels of 
      TGF-beta were measured in PPCM subjects relative to controls. Yet despite these 
      findings, in vitro maturation of normal human cord blood derived progenitor 
      dendritic cells (CBDCs) was significantly reduced (p < 0.001) in the presence of 
      plasma from PPCM patients relative to plasma from post-partum control subjects as 
      determined by expression of CD80, CD86, CD83, CCR7, MHC class II and the ability 
      of these matured CBDCs to induce allo-responses in PBMCs. These results represent 
      the first findings linking inhibition of DC maturation to the dysregulation of 
      normal physiologic cardiac tissue remodeling during pregnancy and the 
      pathogenesis of PPCM.
FAU - Ellis, Jane E
AU  - Ellis JE
AD  - Department of Gynecology and Obstetrics, Emory University School of Medicine, 
      Atlanta, GA 30322, USA.
FAU - Ansari, Aftab A
AU  - Ansari AA
FAU - Fett, James D
AU  - Fett JD
FAU - Carraway, Robert D
AU  - Carraway RD
FAU - Randall, Hugh W
AU  - Randall HW
FAU - Mosunjac, Mario I
AU  - Mosunjac MI
FAU - Sundstrom, J Bruce
AU  - Sundstrom JB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Egypt
TA  - Clin Dev Immunol
JT  - Clinical & developmental immunology
JID - 101183692
RN  - 0 (Antibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Growth Inhibitors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies/blood
MH  - Biomarkers/blood
MH  - Cardiomyopathies/*immunology/physiopathology
MH  - Cell Differentiation/*immunology
MH  - Dendritic Cells/*cytology/*immunology
MH  - Female
MH  - Growth Inhibitors/blood/*physiology
MH  - Humans
MH  - Plasma/*physiology
MH  - Pregnancy/*immunology
MH  - Stem Cells/cytology/immunology
PMC - PMC2270740
EDAT- 2006/04/06 09:00
MHDA- 2009/03/19 09:00
PMCR- 2005/12/01
CRDT- 2006/04/06 09:00
PHST- 2006/04/06 09:00 [pubmed]
PHST- 2009/03/19 09:00 [medline]
PHST- 2006/04/06 09:00 [entrez]
PHST- 2005/12/01 00:00 [pmc-release]
AID - Q1U582T307U73373 [pii]
AID - 10.1080/17402520500304352 [doi]
PST - ppublish
SO  - Clin Dev Immunol. 2005 Dec;12(4):265-73. doi: 10.1080/17402520500304352.