PMID- 16584595
OWN - NLM
STAT- MEDLINE
DCOM- 20071019
LR  - 20161018
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 14
IP  - 1
DP  - 2006 Feb
TI  - [Inhibitory effect of curcumin on angiogenesis induced by brain derived 
      neurotrophic factor from multiple myeloma cells].
PG  - 70-4
AB  - In order to explore the probability of curcumin treating multiple myeloma (MM) 
      via the inhibition of angiogenesis, the expressions of brain derived neurotrophic 
      factor (BDNF) and its specific receptor in human MM cells and endothelial cells 
      were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). The 
      angiogenic activity was evaluated by endothelial cell migration assay and tubule 
      formation assay in vitro. The results showed that exogenous BDNF significantly 
      induced endothelial cell tubule formation and endothelial cell migration, these 
      two effects were inhibited by curcumin. Furthermore, BDNF was detected in the MM 
      cell and TrkB was detected in the endothelial cell and curcumin depressed the 
      mRNA expression of BDNF and TrkB in the dose- and time-dependent manners. It is 
      concluded that BDNF is a novel angiogenesis protein. Curcumin interrupts the 
      interaction between multiple myeloma cells and endothelial cells by reducing TrkB 
      expression in endothelial cells and inhibiting BDNF production in multiple 
      myeloma cells, eventually, resulting in inhibition of angiogenesis. This is 
      probably one part of the mechanism of the curcumin treating MM via the inhibition 
      of angiogenesis.
FAU - Wang, Ya-Dan
AU  - Wang YD
AD  - Institute of Hematology, Union Hospital Affiliated to Tongji Medcal College, 
      Huazhong University of Science and Technology, Wuhan 430022, China.
FAU - Hu, Yu
AU  - Hu Y
FAU - Sun, Chun-Yan
AU  - Sun CY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Angiogenesis Inhibitors/*pharmacology
MH  - Antineoplastic Agents/pharmacology
MH  - Brain-Derived Neurotrophic Factor/*antagonists & inhibitors/biosynthesis/genetics
MH  - Cell Line, Tumor
MH  - Curcumin/*pharmacology
MH  - Endothelial Cells/cytology
MH  - Humans
MH  - Multiple Myeloma/*blood supply/pathology
MH  - Neovascularization, Pathologic/*prevention & control
MH  - RNA, Messenger/biosynthesis/genetics
EDAT- 2006/04/06 09:00
MHDA- 2007/10/20 09:00
CRDT- 2006/04/06 09:00
PHST- 2006/04/06 09:00 [pubmed]
PHST- 2007/10/20 09:00 [medline]
PHST- 2006/04/06 09:00 [entrez]
AID - 1009-2137(2006)01-0070-05 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Feb;14(1):70-4.