PMID- 16584643
OWN - NLM
STAT- MEDLINE
DCOM- 20060427
LR  - 20061115
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 119
IP  - 6
DP  - 2006 Mar 20
TI  - HLA-DRB genotype and specific IgE responses in patients with allergies to 
      penicillins.
PG  - 458-66
AB  - BACKGROUND: Because of the pivotal role of the human leukocyte antigen (HLA) 
      class II molecules in regulating the immune response and their extensive 
      polymorphism, it is not surprising that particular HLA class II alleles have been 
      implicated in susceptibility to allergic diseases and in restriction of the IgE 
      responses to a variety of allergens. We investigated the relationship between 
      HLA-DRB genotype and allergies to various penicillins and explored HLA-DRB 
      restriction of IgE responses to these derivatives of penicillin. METHODS: 
      Radioallergosorbent test was used to examine 8 kinds of specific IgE antibodies 
      (4 major and 4 minor antigenic determinants) in the sera of 248 patients with an 
      allergy to penicillins and 101 healthy subjects without any allergic reaction. 
      Some (113 patients and 87 healthy control subjects) were chosen from all subjects 
      to type for HLA-DRB alleles by sequence specific primer-polymerase chain 
      reaction. RESULTS: Compared with control subjects, a significantly increased 
      frequency of DR9 was present in 77 patients with allergic reactions, with 
      immediate hypersensitive reaction and with urticaria (P = 0.011; P = 0.019; P = 
      0.005 respectively). Conversely, a significantly decreased frequency of DR14.1 
      was found in 80 patients with positive IgE antibodies, with immediate reaction 
      and with urticaria compared with control group (P = 0.024; P = 0.038; P = 0.038). 
      A possible excess of HLA-DR17 was found in subjects who were responsive to 
      benzylpenicilloyl compared with those were not (chi(2) = 5.134, P = 0.023), and 
      of HLA-DR4 was found in subjects responsive to phenoxomethylpenicillanyl (PVA, 
      chi(2) = 4.057, P = 0.044). CONCLUSION: HLA-DRB gene may be involved in allergy 
      to penicillins through modulating specific serum IgE to penicillins.
FAU - Yang, Jing
AU  - Yang J
AD  - Department of Clinical Pharmacology, School of Medicine, Zhengzhou University, 
      Zhengzhou 450052, China.
FAU - Qiao, Hai-ling
AU  - Qiao HL
FAU - Zhang, Yue-wen
AU  - Zhang YW
FAU - Jia, Lin-jing
AU  - Jia LJ
FAU - Tian, Xin
AU  - Tian X
FAU - Gao, Na
AU  - Gao N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Penicillins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Child
MH  - Child, Preschool
MH  - Drug Hypersensitivity/*genetics/immunology
MH  - Female
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Penicillins/adverse effects/*immunology
EDAT- 2006/04/06 09:00
MHDA- 2006/04/28 09:00
CRDT- 2006/04/06 09:00
PHST- 2006/04/06 09:00 [pubmed]
PHST- 2006/04/28 09:00 [medline]
PHST- 2006/04/06 09:00 [entrez]
PST - ppublish
SO  - Chin Med J (Engl). 2006 Mar 20;119(6):458-66.