PMID- 1658967
OWN - NLM
STAT- MEDLINE
DCOM- 19911204
LR  - 20191028
IS  - 0896-0569 (Print)
IS  - 0896-0569 (Linking)
VI  - 14
DP  - 1991
TI  - Involvement of the extrinsic pathway in the activities of low molecular weight 
      heparins.
PG  - 19-27
AB  - Anticoagulant effects of the three LMW heparins (LMWHs) Enoxaparine, Fragmin, 
      Logiparin and of unfractionated heparin (UFH) were compared. The heparins were 
      added to plasma to nominal concentration of 0.2 and 0.5 anti XaU/ml plasma. 
      Dilute tissue thromboplastin (TTP) and CaCl2 were added to platelet poor plasma 
      (PPP), platelet rich plasma (PRP) and citrated blood. Thrombin activity was 
      recorded with chromogenic substrate. In PPP, UFH was definitely more inhibitory 
      than LMWH. In PRP, 0.2 U/ml of LMWHs were about as effective as UFH. At 0.5 U/ml 
      PRP, UFH and Logiparin were more effective than Enoxaparine and Fragmin. Factor 
      XII deficient plasma was very sensitive to heparin, and UFH and Logiparin were 
      again more inhibitory. In whole blood, fibrinopeptide A determinations showed 
      that UFH was more inhibitory than LMWH. We conclude that the net anticoagulant 
      effects of these heparins result from interactions with platelets in addition to 
      accelerated inactivation of clotting factors. The in vivo anticoagulant effect of 
      these drugs can therefore not be predicted from their nominal anti Xa and anti 
      IIa effects alone.
FAU - Norrheim, L
AU  - Norrheim L
AD  - Haematological Research Laboratory, Aker Hospital, Oslo, Norway.
FAU - Abildgaard, U
AU  - Abildgaard U
FAU - Larsen, M L
AU  - Larsen ML
FAU - Lindahl, A K
AU  - Lindahl AK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Thromb Res Suppl
JT  - Thrombosis research. Supplement
JID - 8309239
RN  - 0 (Factor Xa Inhibitors)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 25422-31-5 (Fibrinopeptide A)
RN  - 9001-26-7 (Prothrombin)
RN  - 9002-04-4 (Factor IIa)
RN  - 9005-49-6 (Heparin)
RN  - 9035-58-9 (Thromboplastin)
SB  - IM
MH  - Blood Coagulation/*drug effects
MH  - Blood Coagulation Tests
MH  - Blood Platelets/*drug effects
MH  - Enzyme Activation/drug effects
MH  - Factor XII Deficiency/blood
MH  - Factor Xa Inhibitors
MH  - Fibrinopeptide A/analysis
MH  - Heparin/pharmacology
MH  - Heparin, Low-Molecular-Weight/*pharmacology
MH  - Humans
MH  - Prothrombin/antagonists & inhibitors
MH  - Thromboplastin/pharmacology
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1016/0049-3848(91)90400-q [doi]
PST - ppublish
SO  - Thromb Res Suppl. 1991;14:19-27. doi: 10.1016/0049-3848(91)90400-q.