PMID- 16594940
OWN - NLM
STAT- MEDLINE
DCOM- 20060606
LR  - 20151119
IS  - 1323-1316 (Print)
IS  - 1323-1316 (Linking)
VI  - 60
IP  - 2
DP  - 2006 Apr
TI  - Distress and functioning in mixed anxiety and depressive disorder.
PG  - 168-73
AB  - The aim of the present study was to evaluate the validity of mixed anxiety and 
      depressive disorder (MADD) with reference to functional characteristics and 
      symptomatic characteristics in comparison with anxiety disorders, depressive 
      disorders, and groups showing subthreshold symptoms (exclusively depressive or 
      anxiety related). The present study was carried out in the following three 
      medical settings: two psychiatric and one primary care. Patients seeking care in 
      psychiatric institutions due to anxiety and depressive symptoms and attending 
      primary medical settings for any reason were taken into account. A total of 104 
      patients (65 women and 39 men, mean age 41.1 years) were given a General Health 
      Questionnaire (GHQ-30), Global Assessment of Functioning (GAF) and Present State 
      Examination questionnaire, a part of Schedules for Clinical Assessment in 
      Neuropsychiatry, Version 2.0. There were no statistically relevant differences 
      between MADD and anxiety disorders in median GHQ score (19 vs 16) and median GAF 
      score (median 68.5 vs 65). When considering depressive disorders the median GHQ 
      score (28) was higher, and median GAF score (59) was lower than that in MADD. In 
      groups with separated subthreshold anxiety or depressive symptoms, median GHQ 
      scores (12) were lower and median GAF scores (75) were higher than that in MADD. 
      The most frequent symptoms of MADD are symptoms of generalized anxiety disorder 
      (GAD) and depression. Mixed anxiety and depressive disorder differs significantly 
      from GAD only in higher rates of depressed mood and lower rates of somatic 
      anxiety symptoms. Distinction from depression was clearer; six of 10 depressive 
      symptoms are more minor in severity in MADD than in the case of depression. 
      Distress and interference with personal functions in MADD are similar to that of 
      other anxiety disorders. A pattern of MADD symptoms locates this disorder between 
      depression and GAD.
FAU - Malyszczak, Krzysztof
AU  - Malyszczak K
AD  - Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland. 
      durlik@per.wroc.pl
FAU - Pawlowski, Tomasz
AU  - Pawlowski T
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
SB  - IM
MH  - Adult
MH  - Anxiety Disorders/diagnosis/*epidemiology
MH  - Comorbidity
MH  - Demography
MH  - Depression/diagnosis/*epidemiology
MH  - Depressive Disorder/diagnosis/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Severity of Illness Index
MH  - *Surveys and Questionnaires
EDAT- 2006/04/06 09:00
MHDA- 2006/06/07 09:00
CRDT- 2006/04/06 09:00
PHST- 2006/04/06 09:00 [pubmed]
PHST- 2006/06/07 09:00 [medline]
PHST- 2006/04/06 09:00 [entrez]
AID - PCN [pii]
AID - 10.1111/j.1440-1819.2006.01482.x [doi]
PST - ppublish
SO  - Psychiatry Clin Neurosci. 2006 Apr;60(2):168-73. doi: 
      10.1111/j.1440-1819.2006.01482.x.