PMID- 16595998
OWN - NLM
STAT- MEDLINE
DCOM- 20060809
LR  - 20190606
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 45
IP  - 5
DP  - 2006
TI  - Immunosuppressive treatment for mixed connective tissue disease may facilitate 
      the development of adult T cell leukemia/lymphoma in a HTLVI carrier.
PG  - 297-301
AB  - A 66-year-old woman who was positive for human T-lymphotropic virus type I 
      (HTLV-I) antibody developed mixed connective tissue disease (MCTD) with 
      interstitial pneumonia, and was successfully treated with corticosteroid. One 
      year later, under maintenance treatment of prednisolone (PSL), she contracted 
      acute type adult Tcell leukemia/lymphoma (ATLL) without flaring of MCTD. MCTD is 
      considered to be as one of the HTL-V-I-related inflammatory diseases, however the 
      development of ATLL during the treatment of HTL-V-I-related MCTD has not been 
      well studied. Here, we review the literature and raise the issue of the mutual 
      interactions between MCTD-causative anti-HTLV-I immune response and anti-ATLL 
      immune response.
FAU - Fujiwara, Hiroshi
AU  - Fujiwara H
AD  - Division of Hematology and Immunology, Department of Internal Medicine, Kagoshima 
      University, Kagoshima, Sakuragaoka.
FAU - Nakamura, Daisuke
AU  - Nakamura D
FAU - Kukita, Toshimasa
AU  - Kukita T
FAU - Hamada, Heiichiro
AU  - Hamada H
FAU - Ozaki, Atsuo
AU  - Ozaki A
FAU - Matsushita, Kakushi
AU  - Matsushita K
FAU - Matsumoto, Tadashi
AU  - Matsumoto T
FAU - Tei, Chuwa
AU  - Tei C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20060403
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Autoantibodies)
RN  - 0 (Glucocorticoids)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Receptors, Interleukin-2)
RN  - 9PHQ9Y1OLM (Prednisolone)
RN  - EC 2.7.1.21 (Thymidine Kinase)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Aged
MH  - Autoantibodies/blood
MH  - Blotting, Southern
MH  - Fatal Outcome
MH  - Female
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Leukemia-Lymphoma, Adult T-Cell/blood/drug therapy/*immunology
MH  - Lung Diseases, Interstitial/complications
MH  - Methylprednisolone/therapeutic use
MH  - Mixed Connective Tissue Disease/complications/diagnosis/*drug therapy/immunology
MH  - Prednisolone/therapeutic use
MH  - Receptors, Interleukin-2/blood
MH  - Thymidine Kinase/blood
RF  - 21
EDAT- 2006/04/06 09:00
MHDA- 2006/08/10 09:00
CRDT- 2006/04/06 09:00
PHST- 2006/04/06 09:00 [pubmed]
PHST- 2006/08/10 09:00 [medline]
PHST- 2006/04/06 09:00 [entrez]
AID - JST.JSTAGE/internalmedicine/45.1490 [pii]
AID - 10.2169/internalmedicine.45.1490 [doi]
PST - ppublish
SO  - Intern Med. 2006;45(5):297-301. doi: 10.2169/internalmedicine.45.1490. Epub 2006 
      Apr 3.