PMID- 1659670
OWN - NLM
STAT- MEDLINE
DCOM- 19911230
LR  - 20180215
IS  - 1660-8151 (Print)
IS  - 1660-8151 (Linking)
VI  - 59
IP  - 2
DP  - 1991
TI  - Urine calcium excretion, nephrogenous cyclic-adenosine monophosphate and serum 
      parathyroid hormone levels in patients with essential hypertension.
PG  - 226-31
AB  - To evaluate the role of calcium and the parathyroid gland in the pathophysiology 
      of essential hypertension, creatinine clearance, urinary excretion of sodium, 
      calcium and nephrogenous cyclic adenosine monophosphate (NcAMP) and serum 
      parathyroid hormone (PTH) levels were measured in 25 newly diagnosed essentially 
      hypertensive patients before institution of any treatment and in 25 age- and 
      sex-matched normal volunteers. While no significant differences in creatinine 
      clearance, serum total calcium levels or 24-hour sodium excretion existed between 
      the two groups, hypertensives had a higher mean (+/- SD) 24-hour calcium 
      excretion rate (199.0 +/- 44.7 vs. 152.8 +/- 33.6 mg, p less than 0.001), a 
      higher mean NcAMP excretion rate (2.54 +/- 0.8 vs. 1.87 +/- 0.5 nmol/100 ml 
      glomerular filtrate, p less than 0.001) and a higher mean serum PTH concentration 
      (1.87 +/- 0.6 vs. 1.53 +/- 0.4 ng/ml, p less than 0.001) than the normotensives. 
      A significant positive correlation existed between calcium and sodium excretion 
      in both hypertensives (r = 0.66, p less than 0.001)) and normotensives (r = 0.67, 
      p less than 0.001), but given the same levels of creatinine clearance and sodium 
      excretion, hypertensives excreted more calcium than normotensives (p less than 
      0.001)). In both hypertensives and normotensives, serum PTH levels were 
      positively correlated with NcAMP excretion (r = 0.42, p less than 0.05, and r = 
      0.41, p less than 0.05, respectively) and the ratio of urinary sodium to urinary 
      calcium excretion (r = 0.59, p less than 0.001, and r = 0.75, p less than 0.001), 
      respectively). The above results suggest that in essential hypertension, 
      increased activity of parathyroid glands may occur as a consequence of increased 
      urinary calcium losses which are presumably due to an intrinsic defect in renal 
      calcium handling.
FAU - Papagalanis, N D
AU  - Papagalanis ND
AD  - Department of Nephrology, Red Cross Hospital of Athens, Greece.
FAU - Skopelitis, P
AU  - Skopelitis P
FAU - Kourti, A
AU  - Kourti A
FAU - Kostogianni, G
AU  - Kostogianni G
FAU - Karabatsos, A
AU  - Karabatsos A
FAU - Gennadiou, M
AU  - Gennadiou M
FAU - Thomas, S
AU  - Thomas S
FAU - Samartzis, M
AU  - Samartzis M
FAU - Mountokalakis, T
AU  - Mountokalakis T
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Nephron
JT  - Nephron
JID - 0331777
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Phosphates)
RN  - 9NEZ333N27 (Sodium)
RN  - AYI8EX34EU (Creatinine)
RN  - E0399OZS9N (Cyclic AMP)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Blood Pressure
MH  - Calcium/*urine
MH  - Creatinine/metabolism
MH  - Cyclic AMP/*urine
MH  - Female
MH  - Humans
MH  - Hypertension/blood/*physiopathology/urine
MH  - Male
MH  - Parathyroid Hormone/*blood
MH  - Phosphates/blood
MH  - Reference Values
MH  - Regression Analysis
MH  - Sodium/urine
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1159/000186555 [doi]
PST - ppublish
SO  - Nephron. 1991;59(2):226-31. doi: 10.1159/000186555.