PMID- 16596836
OWN - NLM
STAT- MEDLINE
DCOM- 20060720
LR  - 20200225
IS  - 0160-9289 (Print)
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Linking)
VI  - 29
IP  - 3
DP  - 2006 Mar
TI  - Plasma adrenomedullin relation with Doppler-derived dP/dt in patients with 
      congestive heart failure.
PG  - 126-30
AB  - BACKGROUND: Increased circulating adrenomedullin (AM) concentration has been 
      reported in congestive heart failure (HF) and considered as a possible marker of 
      cardiac dysfunction. HYPOTHESIS: The study was undertaken to assess the 
      relationship between circulating AM concentration and left ventricular (LV) 
      functional state, estimated by echo-Doppler techniques in patients with mild to 
      moderate HF and different degrees of LV dysfunction. METHODS: Plasma AM, B-type 
      natriuretic peptide (BNP), and N-terminal (NT) proBNP levels were measured in 55 
      patients with HF (New York Heart Association [NYHA] I n = 8, II n = 26, III n = 
      21) and in 20 controls; dP/dt was calculated by the Doppler tracing of the mitral 
      regurgitation jet. RESULTS: The study was completed in 51 patients. 
      Adrenomedullin levels were higher than in controls (19.2 +/- 1.4 vs. 13.3 +/- 
      0.7, p < 0.005) and elevated in proportion to NYHA functional class. B-type 
      natriuretic peptide and NT-proBNP were 344 +/- 67 vs. 12 +/- 2 pg/ml and 2196 +/- 
      623 vs. 52 +/- 4 pg/ml, respectively (p < 0.0001); dP/dt was better related to AM 
      (r = 0.582, p < 0.001) than to the other peptides. Adrenomedullin was 
      significantly (p < 0.001) different between patients grouped according to the 
      dP/dt cut-off predictive of event-free survival. CONCLUSIONS: The combination of 
      depressed contractility and increased AM may provide a clue for further 
      characterization of the severity of LV dysfunction in HF, independent of baseline 
      LV ejection fraction.
FAU - Morales, Maria-Aurora
AU  - Morales MA
AD  - Cardiology and Cardiovascular Biochemistry Laboratory, CNR Institute of Clinical 
      Physiology, Pisa, Italy. morales@ifc.cnr.it
FAU - Del Ry, Silvia
AU  - Del Ry S
FAU - Startari, Umberto
AU  - Startari U
FAU - Maltinti, Maristella
AU  - Maltinti M
FAU - Prontera, Concetta
AU  - Prontera C
FAU - Emdin, Michele
AU  - Emdin M
FAU - Giannessi, Daniela
AU  - Giannessi D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (Peptides)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 148498-78-6 (Adrenomedullin)
SB  - IM
MH  - Adrenomedullin
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Echocardiography, Doppler/*methods
MH  - Echocardiography, Transesophageal/*methods
MH  - Female
MH  - Heart Failure/*blood/*diagnostic imaging/mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Peptides/*blood
MH  - Predictive Value of Tests
MH  - Probability
MH  - Prognosis
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Survival Analysis
MH  - Ventricular Dysfunction, Left/blood/diagnostic imaging/mortality
PMC - PMC6654163
EDAT- 2006/04/07 09:00
MHDA- 2006/07/21 09:00
PMCR- 2006/12/05
CRDT- 2006/04/07 09:00
PHST- 2006/04/07 09:00 [pubmed]
PHST- 2006/07/21 09:00 [medline]
PHST- 2006/04/07 09:00 [entrez]
PHST- 2006/12/05 00:00 [pmc-release]
AID - CLC4960290309 [pii]
AID - 10.1002/clc.4960290309 [doi]
PST - ppublish
SO  - Clin Cardiol. 2006 Mar;29(3):126-30. doi: 10.1002/clc.4960290309.