PMID- 16597897
OWN - NLM
STAT- MEDLINE
DCOM- 20061114
LR  - 20231103
IS  - 0095-1137 (Print)
IS  - 1098-660X (Electronic)
IS  - 0095-1137 (Linking)
VI  - 44
IP  - 4
DP  - 2006 Apr
TI  - Human herpesvirus 6 chromosomal integration in immunocompetent patients results 
      in high levels of viral DNA in blood, sera, and hair follicles.
PG  - 1571-4
AB  - Six immunocompetent patients with human herpesvirus 6 (HHV-6) chromosomal 
      integration had HHV-6 and beta-globin DNA quantified in various samples by PCR. 
      The mean HHV-6 DNA concentration (log(10) copies/milliliter) in blood was 7.0 
      (>/=1 HHV-6 DNA copies/leukocyte), and in serum it was 5.3 (>/=1 HHV-6 DNA 
      copies/lysed cell). The mean HHV-6 DNA load (log(10) copies)/hair follicle was 
      4.2 (>/=1 copies/hair follicle cell), demonstrating that viral integration is not 
      confined to blood cells. The characteristically high HHV-6 DNA levels in 
      chromosomal integration may confound laboratory diagnosis of HHV-6 infection and 
      should be given due consideration.
FAU - Ward, Katherine N
AU  - Ward KN
AD  - Centre for Virology, Division of Infection and Immunity, Royal Free and 
      University College Medical School (UCL campus), Windeyer Institute of Medical 
      Sciences, 46 Cleveland St., London W1T 4JF, United Kingdom. k.n.ward@ucl.ac.uk
FAU - Leong, Hoe Nam
AU  - Leong HN
FAU - Nacheva, Elisabeth P
AU  - Nacheva EP
FAU - Howard, Julie
AU  - Howard J
FAU - Atkinson, Claire E
AU  - Atkinson CE
FAU - Davies, Nicholas W S
AU  - Davies NW
FAU - Griffiths, Paul D
AU  - Griffiths PD
FAU - Clark, Duncan A
AU  - Clark DA
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 051350/Z/WT_/Wellcome Trust/United Kingdom
GR  - 059040/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Microbiol
JT  - Journal of clinical microbiology
JID - 7505564
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/blood
MH  - DNA, Viral/*blood
MH  - Female
MH  - Hair Follicle/*virology
MH  - Herpesviridae Infections/*immunology/virology
MH  - Herpesvirus 6, Human/*genetics/immunology
MH  - Humans
MH  - Immunocompetence
MH  - Male
MH  - Middle Aged
MH  - Viral Load
MH  - *Virus Integration
PMC - PMC1448653
EDAT- 2006/04/07 09:00
MHDA- 2006/11/15 09:00
PMCR- 2006/08/01
CRDT- 2006/04/07 09:00
PHST- 2006/04/07 09:00 [pubmed]
PHST- 2006/11/15 09:00 [medline]
PHST- 2006/04/07 09:00 [entrez]
PHST- 2006/08/01 00:00 [pmc-release]
AID - 44/4/1571 [pii]
AID - 0291-06 [pii]
AID - 10.1128/JCM.44.4.1571-1574.2006 [doi]
PST - ppublish
SO  - J Clin Microbiol. 2006 Apr;44(4):1571-4. doi: 10.1128/JCM.44.4.1571-1574.2006.