PMID- 16598996
OWN - NLM
STAT- MEDLINE
DCOM- 20060920
LR  - 20161020
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 27
IP  - 1
DP  - 2006 Jan-Feb
TI  - Sensitization to other foods in subjects with reported allergy to grapes.
PG  - 68-71
AB  - The grape is widely produced and consumed in the Mediterranean area. The object 
      of this prospective study was to present in detail the clinical features of 
      patients with documented immunoglobulin E (IgE)-mediated reactions to grapes or 
      its products as well as the existing cosensitizations in other food allergens 
      among this population. Sixty-one patients (27 male patients and 34 female 
      patients), aged 14-52 years (mean, 28.8 years) with a documented history of 
      IgE-mediated reactions to grapes or its products (wine, juice, and wine vinegar) 
      were included in this study. In each patient, full allergological data, clinical 
      examination, and specific in vivo (skin-prick tests and prick-to-prick) and in 
      vitro (grape-specific IgE) evaluations were recorded. The diagnostic procedure 
      was extended in other food allergens and molds for exclusion of fruit surface 
      contamination. Thirty-seven of 61 (60.7%) patients had a positive personal 
      history and 24/61 (39.3%) patients had a family history of atopy. Patients 
      reported 3.1 episodes/patient (range, 1-15 episodes) after consumption of grapes 
      or its product. Forty-seven of 61 (77%) patients had presented oral allergy 
      syndrome after eating grapes before the first reported reaction. The mean time 
      for the onset of symptoms was 42 minutes (4-160 minutes). Forty-four of 61 
      (72.1%) patients reported more than one reaction. The observed prevalence of 
      symptomatology according to the system involved was determined: skin, 
      57/61(93.4%) patients; respiratory, 46/61(75.4%) patients; cardiovascular, 27/61 
      (44.3%) patients; and gastrointestinal, 24/61(39.3%) patients. The main 
      cosensitizations were identified (skin-prick tests): apples, 81.9%; peaches, 
      70.5%; cherries, 47.5%; strawberries, 32.8%; peanuts, 49.2%; walnuts, 42.6%; 
      hazelnuts, 31.1%; almonds, 26.2%; and pistachios, 29.5%. The grape and its 
      products may be the offending agent of IgE-mediated reactions in sensitized 
      individuals. The high prevalence of concomitant reactivity to other fruits 
      elicits the interest of clinical relevance of these findings among the 
      grape-allergic population.
FAU - Kalogeromitros, Dimitrios C
AU  - Kalogeromitros DC
AD  - Allergology Unit, University Hospital Attiko, Athens, Greece. mak-mik@hol.gr
FAU - Makris, Michael P
AU  - Makris MP
FAU - Gregoriou, Stamatios G
AU  - Gregoriou SG
FAU - Katoulis, Alexandros C
AU  - Katoulis AC
FAU - Straurianeas, Nikolaos G
AU  - Straurianeas NG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Allergens
MH  - Cross Reactions
MH  - Female
MH  - Food Hypersensitivity/diagnosis/*etiology
MH  - Fruit/*immunology
MH  - Humans
MH  - Hypersensitivity, Immediate/diagnosis/etiology
MH  - Male
MH  - Middle Aged
MH  - Nuts/immunology
EDAT- 2006/04/08 09:00
MHDA- 2006/09/21 09:00
CRDT- 2006/04/08 09:00
PHST- 2006/04/08 09:00 [pubmed]
PHST- 2006/09/21 09:00 [medline]
PHST- 2006/04/08 09:00 [entrez]
PST - ppublish
SO  - Allergy Asthma Proc. 2006 Jan-Feb;27(1):68-71.