PMID- 16601334
OWN - NLM
STAT- MEDLINE
DCOM- 20060810
LR  - 20161128
IS  - 1015-3837 (Print)
IS  - 1015-3837 (Linking)
VI  - 21
IP  - 3
DP  - 2006
TI  - Sildenafil citrate and fetal outcome in pregnant rats.
PG  - 259-63
AB  - OBJECTIVE: To determine the effects of sildenafil citrate on fetal growth in 
      maternal rats exposed to hypoxia. METHODS: Timed pregnant rats were randomized to 
      either hypoxia or control on gestational days (GD) 18-20, and received either 
      sildenafil (45 mg/kg) orally every 12 h on GD 18-21 or an equal volume of sterile 
      water. Fetal pups were retrieved by laparotomy on GD 21. Pup weight and length 
      were evaluated and cGMP measured in maternal and fetal blood. RESULTS: In the 
      non-hypoxic rats, sildenafil exposure was associated with a decrease in size(4.75 
      +/- 0.43 vs. 5.11 +/- 0.34 g, p = 0.00). In contrast, in the hypoxic rat model, 
      sildenafil exposure was associated with increased size of the offspring (5.48 +/- 
      0.45 vs. 5.16 +/- 0.36 g, p = 0.016). Maternal cGMP levels were increased in the 
      presence of both sildenafil and hypoxia (23.0 +/- 10.5 vs. 15.6 +/- 2.7 pmol/ml, 
      p = 0.001). CONCLUSION: Exposure to sildenafil in a non-hypoxic setting results 
      in a decrease in fetal size. Sildenafil in the presence of a stimulus, hypoxia, 
      will lead to increased fetal size. These results suggest that sildenafil may have 
      some influence on fetal growth. How these effects occur and by what mechanism 
      remain to be determined.
CI  - Copyright 2006 S. Karger AG, Basel.
FAU - Refuerzo, Jerrie S
AU  - Refuerzo JS
AD  - Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, 
      Wayne State University, Detroit, MI 48201, USA. jrefuerz@med.wayne.edu
FAU - Sokol, Robert J
AU  - Sokol RJ
FAU - Aranda, Jacob V
AU  - Aranda JV
FAU - Hallak, Mordechai
AU  - Hallak M
FAU - Hotra, John W
AU  - Hotra JW
FAU - Kruger, Michael
AU  - Kruger M
FAU - Sorokin, Yoram
AU  - Sorokin Y
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Fetal Diagn Ther
JT  - Fetal diagnosis and therapy
JID - 9107463
RN  - 0 (Piperazines)
RN  - 0 (Purines)
RN  - 0 (Sulfones)
RN  - BW9B0ZE037 (Sildenafil Citrate)
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Animals
MH  - Cyclic GMP/blood
MH  - Female
MH  - Fetal Development/*drug effects
MH  - Fetal Weight/drug effects
MH  - Gestational Age
MH  - Hypoxia/complications
MH  - Piperazines/*administration & dosage/adverse effects
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - Purines
MH  - Rats
MH  - Sildenafil Citrate
MH  - Sulfones
EDAT- 2006/04/08 09:00
MHDA- 2006/08/11 09:00
CRDT- 2006/04/08 09:00
PHST- 2005/02/18 00:00 [received]
PHST- 2005/05/17 00:00 [accepted]
PHST- 2006/04/08 09:00 [pubmed]
PHST- 2006/08/11 09:00 [medline]
PHST- 2006/04/08 09:00 [entrez]
AID - 91352 [pii]
AID - 10.1159/000091352 [doi]
PST - ppublish
SO  - Fetal Diagn Ther. 2006;21(3):259-63. doi: 10.1159/000091352.