PMID- 16602563
OWN - NLM
STAT- MEDLINE
DCOM- 20060502
LR  - 20191210
IS  - 0018-9294 (Print)
IS  - 0018-9294 (Linking)
VI  - 53
IP  - 4
DP  - 2006 Apr
TI  - Cardiac anisotropy: is it negligible regarding noninvasive activation time 
      imaging?
PG  - 569-80
AB  - The aim of this study was to quantify the effect of cardiac anisotropy in the 
      activation-based inverse problem of electrocardiography. Differences of the 
      patterns of simulated body surface potential maps for isotropic and anisotropic 
      conditions were investigated with regard to activation time (AT) imaging of 
      ventricular depolarization. AT maps were estimated by solving the nonlinear 
      inverse ill-posed problem employing spatio-temporal regularization. Four 
      different reference AT maps (sinus rhythm, right-ventricular and septal pacing, 
      accessory pathway) were calculated with a bidomain theory based anisotropic 
      finite-element heart model in combination with a cellular automaton. In this 
      heart model a realistic fiber architecture and conduction system was implemented. 
      Although the anisotropy has some effects on forward solutions, effects on inverse 
      solutions are small indicating that cardiac anisotropy might be negligible for 
      some clinical applications (e.g., imaging of focal events) of our AT imaging 
      approach. The main characteristic events of the AT maps were estimated despite 
      neglected electrical anisotropy in the inverse formulation. The worst correlation 
      coefficient of the estimated AT maps was 0.810 in case of sinus rhythm. However, 
      all characteristic events of the activation pattern were found. The results of 
      this study confirm our clinical validation studies of noninvasive AT imaging in 
      which cardiac anisotropy was neglected.
FAU - Modre, Robert
AU  - Modre R
AD  - University for Health Sciences, Medical Informatics and Technology (UMIT), Hall 
      in Tirol 6060, Austria. robert.modre@arcsmed.at
FAU - Seger, Michael
AU  - Seger M
FAU - Fischer, Gerald
AU  - Fischer G
FAU - Hintermuller, Christoph
AU  - Hintermuller C
FAU - Hayn, Dieter
AU  - Hayn D
FAU - Pfeifer, Bernhard
AU  - Pfeifer B
FAU - Hanser, Friedrich
AU  - Hanser F
FAU - Schreier, Gunter
AU  - Schreier G
FAU - Tilg, Bernhard
AU  - Tilg B
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - IEEE Trans Biomed Eng
JT  - IEEE transactions on bio-medical engineering
JID - 0012737
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Body Surface Potential Mapping/*methods
MH  - Computer Simulation
MH  - Diagnosis, Computer-Assisted/*methods
MH  - Heart Conduction System/*physiology
MH  - Humans
MH  - *Models, Cardiovascular
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Ventricular Function
EDAT- 2006/04/11 09:00
MHDA- 2006/05/04 09:00
CRDT- 2006/04/11 09:00
PHST- 2006/04/11 09:00 [pubmed]
PHST- 2006/05/04 09:00 [medline]
PHST- 2006/04/11 09:00 [entrez]
AID - 10.1109/TBME.2006.870253 [doi]
PST - ppublish
SO  - IEEE Trans Biomed Eng. 2006 Apr;53(4):569-80. doi: 10.1109/TBME.2006.870253.