PMID- 16603113
OWN - NLM
STAT- MEDLINE
DCOM- 20060613
LR  - 20061115
IS  - 1548-825X (Print)
IS  - 1548-825X (Linking)
VI  - 15
IP  - 1
DP  - 2006 Spring
TI  - Hylan G-F 20 tolerability with repeat treatment in a large orthopedic practice: a 
      retrospective review.
PG  - 53-9
AB  - The objective of this study was to determine the incidence of local adverse 
      events (AEs) with repeat treatment of hylan G-F 20 for osteoarthritis (OA) knee 
      pain relief in the authors' practice. Prospectively collected patient data 
      (5-year period) was retrospectively reviewed from patients who initiated multiple 
      courses of three weekly hylan G-F 20 injections. All local AEs (knee pain and 
      swelling) were qualitatively and quantitatively assessed. The incidence of 
      treatment-related local AEs was 3.4% of patients (0.8% of injections) at course 
      1, 13.1% of patients (4.3% of injections) at course 2, and 17.3% of patients 
      (5.4% of injections) at course 3. The majority of related local AEs were mild to 
      moderate and persisted for < or = 48 hours. The number of patients who 
      discontinued injections because of local AEs was low. While the incidence of 
      local AEs with hylan G-F 20 tends to slightly increase with subsequent courses of 
      therapy, physicians should educate patients regarding this possibility rather 
      than preclude them from the benefit of continued OA pain relief with repeat hylan 
      G-F 20 therapy.
FAU - Waddell, David D
AU  - Waddell DD
AD  - Orthopedic Specialists of Louisiana, 2900 Hearne Avenue, Shreveport, LA 71103, 
      USA. oslresearch@aol.com
FAU - Bricker, Dewayne C
AU  - Bricker DC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Surg Orthop Adv
JT  - Journal of surgical orthopaedic advances
JID - 101197881
RN  - 125935-84-4 (hylan)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Hyaluronic Acid/administration & dosage/adverse effects/*analogs & derivatives
MH  - Injections, Intra-Articular
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*drug therapy
MH  - Retreatment
MH  - Retrospective Studies
EDAT- 2006/04/11 09:00
MHDA- 2006/06/14 09:00
CRDT- 2006/04/11 09:00
PHST- 2006/04/11 09:00 [pubmed]
PHST- 2006/06/14 09:00 [medline]
PHST- 2006/04/11 09:00 [entrez]
AID - 15-1-8.pdf?T=open_article,920234 [pii]
PST - ppublish
SO  - J Surg Orthop Adv. 2006 Spring;15(1):53-9.