PMID- 16603420 OWN - NLM STAT- MEDLINE DCOM- 20060925 LR - 20131121 IS - 1566-0702 (Print) IS - 1566-0702 (Linking) VI - 126-127 DP - 2006 Jun 30 TI - Involvement of the medial prefrontal cortex in central cardiovascular modulation in the rat. PG - 130-8 AB - The medial prefrontal cortex (MPFC) and specifically its ventral portion (vMPFC) have been reported to modulate autonomic responses. On the cardiovascular system, this modulation is characterized by an influence on arterial blood pressure, regional blood flow as well as cardiac sympathetic and parasympathetic responses. The vMPFC also modulates baroreflex activity. Several neurotransmitters are present in the vMPFC. Among them L-glutamate, acetylcholine and noradrenaline are involved with cardiovascular modulation. In the present review, we describe evidences on the mechanisms involved in the vMPFC-related cardiovascular modulation. FAU - Resstel, L B M AU - Resstel LB AD - Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, 14090-090, Brazil. leoresstel@yahoo.com.br FAU - Correa, F M A AU - Correa FM LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20060417 PL - Netherlands TA - Auton Neurosci JT - Autonomic neuroscience : basic & clinical JID - 100909359 RN - 3KX376GY7L (Glutamic Acid) RN - N9YNS0M02X (Acetylcholine) RN - X4W3ENH1CV (Norepinephrine) SB - IM MH - Acetylcholine/metabolism MH - Animals MH - Baroreflex/drug effects/physiology MH - Blood Pressure/physiology MH - Cardiovascular System/*innervation MH - Glutamic Acid/metabolism MH - Heart Rate/physiology MH - Norepinephrine/metabolism MH - Prefrontal Cortex/*physiology MH - Rats MH - Reversal Learning/physiology RF - 79 EDAT- 2006/04/11 09:00 MHDA- 2006/09/26 09:00 CRDT- 2006/04/11 09:00 PHST- 2005/10/13 00:00 [received] PHST- 2006/02/21 00:00 [revised] PHST- 2006/02/27 00:00 [accepted] PHST- 2006/04/11 09:00 [pubmed] PHST- 2006/09/26 09:00 [medline] PHST- 2006/04/11 09:00 [entrez] AID - S1566-0702(06)00072-5 [pii] AID - 10.1016/j.autneu.2006.02.022 [doi] PST - ppublish SO - Auton Neurosci. 2006 Jun 30;126-127:130-8. doi: 10.1016/j.autneu.2006.02.022. Epub 2006 Apr 17.