PMID- 16603552 OWN - NLM STAT- MEDLINE DCOM- 20060511 LR - 20190702 IS - 0042-4900 (Print) IS - 0042-4900 (Linking) VI - 158 IP - 14 DP - 2006 Apr 8 TI - Randomised, placebo-controlled trial of a live vaccine against porcine reproductive and respiratory syndrome virus in sows on infected farms. PG - 475-8 AB - A randomised, double-blinded, placebo-controlled study into the effectiveness and safety of a vaccine against porcine reproductive and respiratory syndrome virus (PRRSV) was carried out on three farms with a history compatible with chronic PRRSV infection; representative groups of sows and gilts were injected with a live vaccine against PRRSV, and during the next six weeks no side effects were observed. The remaining sows and gilts on the three farms were then vaccinated with the same vaccine. Again, no side effects were observed. There were significant reductions in abortion, reproductive disease, returns to oestrus and the numbers of stillborn pigs per sow, and significant increases in the numbers of liveborn pigs per sow and weaned pigs per sow among the vaccinated animals. FAU - Pejsak, Z AU - Pejsak Z AD - Swine Diseases Department, National Veterinary Research Institute, Al Partyzantow 57, 24-100 Pulawy, Poland. FAU - Markowska-Daniel, I AU - Markowska-Daniel I LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Vet Rec JT - The Veterinary record JID - 0031164 RN - 0 (Viral Vaccines) SB - IM MH - Animals MH - Double-Blind Method MH - Female MH - Poland/epidemiology MH - Porcine Reproductive and Respiratory Syndrome/epidemiology/*prevention & control MH - Porcine respiratory and reproductive syndrome virus/*immunology MH - Swine MH - Treatment Outcome MH - Vaccination/*veterinary MH - Viral Vaccines/*immunology EDAT- 2006/04/11 09:00 MHDA- 2006/05/12 09:00 CRDT- 2006/04/11 09:00 PHST- 2006/04/11 09:00 [pubmed] PHST- 2006/05/12 09:00 [medline] PHST- 2006/04/11 09:00 [entrez] AID - 158/14/475 [pii] AID - 10.1136/vr.158.14.475 [doi] PST - ppublish SO - Vet Rec. 2006 Apr 8;158(14):475-8. doi: 10.1136/vr.158.14.475.