PMID- 16605126
OWN - NLM
STAT- MEDLINE
DCOM- 20060627
LR  - 20071114
IS  - 1528-2511 (Print)
IS  - 1528-2511 (Linking)
VI  - 271
DP  - 2005
TI  - Immune sensitization in the skin is enhanced by antigen-independent effects of 
      IgE on mast cells.
PG  - 15-24; discussion 24-38, 95-9
AB  - Contact sensitivity responses require both effective immune sensitization 
      following cutaneous exposure to chemical haptens and antigen-specific elicitation 
      of inflammation upon subsequent hapten challenge. We have observed that that 
      antigen-independent effects of immunoglobulin E (IgE) antibodies promote immune 
      sensitization to haptens in the skin. Contact sensitivity is markedly impaired in 
      IgE-/- mice but can be restored by either transfer of sensitized cells from 
      wild-type mice or administration of hapten-irrelevant IgE before sensitization. 
      Moreover, IgE-/- mice exhibit impairment in the emigration of dendritic cells 
      from the epidermis after hapten exposure. Monomeric IgE has been reported to 
      influence mast cell function. We observe diminished contact sensitivity in mice 
      lacking FcepsilonRI or mast cells, and mRNA for several mast cell-associated 
      genes is reduced in IgE-/- vs. wild-type skin after hapten exposure. We propose 
      that levels of IgE normally present in mice favour immune sensitization via 
      antigen-independent effects on mast cells.
FAU - Bryce, Paul J
AU  - Bryce PJ
AD  - Division of Immunology, Children's Hospital, Boston, MA 02115, USA.
FAU - Miller, Mendy L
AU  - Miller ML
FAU - Miyajima, Ichiro
AU  - Miyajima I
FAU - Tsai, Mindy
AU  - Tsai M
FAU - Galli, Stephen J
AU  - Galli SJ
FAU - Oettgen, Hans C
AU  - Oettgen HC
LA  - eng
GR  - 1-R01-AI054471/AI/NIAID NIH HHS/United States
GR  - P01-HL67674/HL/NHLBI NIH HHS/United States
GR  - R01-CA72074/CA/NCI NIH HHS/United States
GR  - R37-AI23990/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Novartis Found Symp
JT  - Novartis Foundation symposium
JID - 9807767
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Cytokines)
RN  - 0 (Haptens)
RN  - 0 (Receptors, IgE)
RN  - 0 (Stem Cell Factor)
RN  - 15646-46-5 (Oxazolone)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adjuvants, Immunologic
MH  - Administration, Cutaneous
MH  - Animals
MH  - Cytokines/genetics/immunology
MH  - Dermatitis, Contact/*immunology
MH  - Haptens/immunology
MH  - Humans
MH  - Hypersensitivity, Immediate
MH  - Immunoglobulin E/genetics/*immunology
MH  - Mast Cells/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Knockout
MH  - Oxazolone/immunology
MH  - Receptors, IgE/immunology
MH  - Skin/*immunology
MH  - Stem Cell Factor/genetics/immunology
EDAT- 2006/04/12 09:00
MHDA- 2006/06/28 09:00
CRDT- 2006/04/12 09:00
PHST- 2006/04/12 09:00 [pubmed]
PHST- 2006/06/28 09:00 [medline]
PHST- 2006/04/12 09:00 [entrez]
PST - ppublish
SO  - Novartis Found Symp. 2005;271:15-24; discussion 24-38, 95-9.