PMID- 16606409
OWN - NLM
STAT- MEDLINE
DCOM- 20060830
LR  - 20060411
IS  - 0905-4383 (Print)
IS  - 0905-4383 (Linking)
VI  - 22
IP  - 2
DP  - 2006 Apr
TI  - Association of HLA subtype DRB10407 in Colombian patients with actinic prurigo.
PG  - 55-8
AB  - BACKGROUND: Human leukocyte antigen (HLA) DRB1*0407 had been associated with 
      actinic prurigo in different populations. This class II HLA-DR subtype had not 
      been studied in Colombia. OBJECTIVE: The objective of this study was to establish 
      whether there was an association of actinic prurigo with HLA DR in a Colombian 
      population. MATERIALS AND METHODS: Forty patients with a clinical diagnosis of 
      actinic prurigo and 40 healthy subjects, paired by age, sex and birthplace, were 
      studied. HLA typing for HLA DRB1 and DRB1*04, if necessary, was performed by the 
      PCR-SSP method using blood samples. RESULTS: A high frequency of HLA DRB1*0407 
      was found in the patients (97.5% vs. 30%; P<0.00001). The allelic frequency of 
      HLA DRB1*0407 was 63.8% in the case group, and 14.5% in the controls (P<0.00001). 
      In the control group, there was a higher frequency of the alleles DRB1*01 (14.5% 
      vs. 1.25%; P=0.0027) and DRB1*13 (23.7% vs. 2.5%; P=0.00013). LIMITATIONS: The 
      small number of controls does not allow us to drive conclusions about other HLA 
      alleles. CONCLUSIONS: HLA subtype DRB1*0407, found in actinic prurigo patients in 
      studies conducted in England, Scotland, Ireland and Mexico, was also associated 
      in Colombian patients. This finding, concordant in patients from different ethnic 
      groups, could be helpful in the diagnosis of this disease and probably important 
      in its pathogenesis. DRB1*01 and DRB1*13 alleles were more frequent in controls 
      than in patients; we do not know whether they play any role in the resistance to 
      the disease.
FAU - Suarez, Alfonso
AU  - Suarez A
AD  - Centro Dermatologico Federico Lleras Acosta, E.S.E. Bogota, Colombia.
FAU - Valbuena, Martha Cecilia
AU  - Valbuena MC
FAU - Rey, Maritza
AU  - Rey M
FAU - de Porras Quintana, Luisa
AU  - de Porras Quintana L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Photodermatol Photoimmunol Photomed
JT  - Photodermatology, photoimmunology & photomedicine
JID - 9013641
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Colombia
MH  - Female
MH  - HLA-DR Antigens/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Photosensitivity Disorders/*immunology
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single-Stranded Conformational
MH  - Prurigo/*immunology
EDAT- 2006/04/12 09:00
MHDA- 2006/08/31 09:00
CRDT- 2006/04/12 09:00
PHST- 2006/04/12 09:00 [pubmed]
PHST- 2006/08/31 09:00 [medline]
PHST- 2006/04/12 09:00 [entrez]
AID - PPP205 [pii]
AID - 10.1111/j.1600-0781.2006.00205.x [doi]
PST - ppublish
SO  - Photodermatol Photoimmunol Photomed. 2006 Apr;22(2):55-8. doi: 
      10.1111/j.1600-0781.2006.00205.x.