PMID- 16608514 OWN - NLM STAT- MEDLINE DCOM- 20060713 LR - 20211020 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 5 DP - 2006 Apr 11 TI - Soy protein supplementation does not cause lymphocytopenia in postmenopausal women. PG - 12 AB - BACKGROUND: The health benefits of soy isoflavones have been widely investigated; however, there are some concerns as to whether soy isoflavones, similar to ipriflavone, a synthetic isoflavone, cause lymphocytopenia in postmenopausal women. Hence, the purpose of this study was to investigate the extent to which 12-month supplementation of 25 g soy protein containing 60 mg isoflavones alters lymphocyte counts or other hematological parameters in postmenopausal women who were not on hormone replacement therapy. METHODS: Eighty-seven postmenopausal women were randomly assigned to receive either soy protein or an equivalent amount of control protein devoid of isoflavones. Fasting venous blood was collected at baseline and at the end of twelve month study period for complete blood count analyses. RESULTS: Between the two treatment groups, the percent changes in hematological parameters, including lymphocytes, were not different. While women consuming the soy supplement had an increase in mean corpuscular hemoglobin concentration (MCHC) and red cell distribution width index (RDW; a marker of reticulocytes), women consuming the control diet had higher percentage of only MCHC. CONCLUSION: Overall, the results of the present study indicate that consumption of 25 g soy protein containing 60 mg isoflavones daily for one year does not cause lymphocytopenia. FAU - Soung, Do Y AU - Soung do Y AD - Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL, USA. doyu@okstate.edu FAU - Patade, Anagha AU - Patade A FAU - Khalil, Dania A AU - Khalil DA FAU - Lucas, Edralin A AU - Lucas EA FAU - Devareddy, Latha AU - Devareddy L FAU - Greaves, Kathryn A AU - Greaves KA FAU - Arjmandi, Bahram H AU - Arjmandi BH LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20060411 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Isoflavones) RN - 0 (Soybean Proteins) SB - IM MH - Aged MH - Basophils MH - Diet MH - Erythrocyte Indices MH - Female MH - Humans MH - Isoflavones/administration & dosage/adverse effects MH - Leukocyte Count MH - Lymphopenia/*chemically induced MH - Middle Aged MH - Monocytes MH - Platelet Count MH - *Postmenopause MH - Soybean Proteins/administration & dosage/*adverse effects/chemistry PMC - PMC1481570 EDAT- 2006/04/13 09:00 MHDA- 2006/07/14 09:00 PMCR- 2006/04/11 CRDT- 2006/04/13 09:00 PHST- 2005/11/10 00:00 [received] PHST- 2006/04/11 00:00 [accepted] PHST- 2006/04/13 09:00 [pubmed] PHST- 2006/07/14 09:00 [medline] PHST- 2006/04/13 09:00 [entrez] PHST- 2006/04/11 00:00 [pmc-release] AID - 1475-2891-5-12 [pii] AID - 10.1186/1475-2891-5-12 [doi] PST - epublish SO - Nutr J. 2006 Apr 11;5:12. doi: 10.1186/1475-2891-5-12.