PMID- 1660964
OWN - NLM
STAT- MEDLINE
DCOM- 19920123
LR  - 20181130
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 54
IP  - 5
DP  - 1991 Nov
TI  - Stimulation of adrenocorticotropin but not prolactin and catecholamine release by 
      N-methyl-aspartic acid.
PG  - 488-92
AB  - The aim of this study was to elucidate the effects of N-methyl-D-aspartic acid 
      (NMDA) receptor stimulation on the release of several hormones known to be 
      activated during stress. The experiments were performed in conscious freely 
      moving cannulated rats. Systemic administration of N-methyl-D,L-aspartic acid 
      (NMA) and of NMDA in low doses (2.5-10 mg/kg i.p.) was found to induce a 
      dose-related stimulation of adrenocorticotropin (ACTH) release. NMA-induced ACTH 
      release was reduced by administration of an NMDA receptor antagonist 
      (D,L-2-amino-5-phosphonovaleric acid). NMDA was much more potent in activating 
      ACTH release than the racemic form of the amino acid, NMA. In the dose range 
      used, both NMA and NMDA failed to influence prolactin release. With the exception 
      of a small increase in epinephrine concentration in response to the highest dose 
      of NMDA (10 mg/kg), no changes in plasma catecholamines were observed. The data 
      indicate that NMA and NMDA administered in low doses trigger ACTH release without 
      induction of a nonspecific stress response.
FAU - Jezova, D
AU  - Jezova D
AD  - Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, 
      Czechoslovakia.
FAU - Oliver, C
AU  - Oliver C
FAU - Jurcovicova, J
AU  - Jurcovicova J
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9002-62-4 (Prolactin)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adrenocorticotropic Hormone/*metabolism
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Epinephrine/*metabolism
MH  - Kinetics
MH  - Male
MH  - N-Methylaspartate/administration & dosage/*pharmacology
MH  - Norepinephrine/*metabolism
MH  - Prolactin/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1991/11/01 00:00
MHDA- 1991/11/01 00:01
CRDT- 1991/11/01 00:00
PHST- 1991/11/01 00:00 [pubmed]
PHST- 1991/11/01 00:01 [medline]
PHST- 1991/11/01 00:00 [entrez]
AID - 10.1159/000125942 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1991 Nov;54(5):488-92. doi: 10.1159/000125942.