PMID- 16611055
OWN - NLM
STAT- MEDLINE
DCOM- 20060622
LR  - 20191109
IS  - 1570-162X (Print)
IS  - 1570-162X (Linking)
VI  - 4
IP  - 2
DP  - 2006 Apr
TI  - Viral piracy: HIV-1 targets dendritic cells for transmission.
PG  - 169-76
AB  - Dendritic cells (DCs), the professional antigen presenting cells, are critical 
      for host immunity by inducing specific immune responses against a broad variety 
      of pathogens. Remarkably the human immunodeficiency virus-1 (HIV-1) subverts DC 
      function leading to spread of the virus. At an early phase of HIV-1 transmission, 
      DCs capture HIV-1 at mucosal surfaces and transmit the virus to T cells in 
      secondary lymphoid tissues. Capture of the virus on DCs takes place via C-type 
      lectins of which the dendritic cell-specific intercellular adhesion molecule-3 
      (ICAM-3) grabbing nonintegrin (DC-SIGN) is the best studied. DC-SIGN-captured 
      HIV-1 particles accumulate in CD81(+) multivesicular bodies (MVBs) in DCs and are 
      subsequently transmitted to CD4+ T cells resulting in infection of T cells. The 
      viral cell-to-cell transmission takes place at the DC-T cell interface termed the 
      infectious synapse. Recent studies demonstrate that direct infection of DCs 
      contributes to the transmission to T cells at a later phase. Moreover, the 
      infected DCs may function as cellular reservoirs for HIV-1. This review discusses 
      the different processes that govern viral piracy of DCs by HIV-1, emphasizing the 
      intracellular routing of the virus from capture on the cell surface to egress in 
      the infectious synapse.
FAU - Lekkerkerker, Annemarie N
AU  - Lekkerkerker AN
AD  - Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical 
      Center Amsterdam, v.d. Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.
FAU - van Kooyk, Yvette
AU  - van Kooyk Y
FAU - Geijtenbeek, Teunis B H
AU  - Geijtenbeek TB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Curr HIV Res
JT  - Current HIV research
JID - 101156990
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Cell Adhesion Molecules/immunology
MH  - Cell Movement/immunology
MH  - Dendritic Cells/immunology/*virology
MH  - HIV Infections/*immunology/*transmission/virology
MH  - HIV-1/*immunology
MH  - Humans
MH  - Lectins, C-Type/immunology
MH  - Macaca
MH  - Receptors, Cell Surface/immunology
MH  - T-Lymphocytes/immunology/virology
RF  - 79
EDAT- 2006/04/14 09:00
MHDA- 2006/06/23 09:00
CRDT- 2006/04/14 09:00
PHST- 2006/04/14 09:00 [pubmed]
PHST- 2006/06/23 09:00 [medline]
PHST- 2006/04/14 09:00 [entrez]
AID - 10.2174/157016206776055020 [doi]
PST - ppublish
SO  - Curr HIV Res. 2006 Apr;4(2):169-76. doi: 10.2174/157016206776055020.