PMID- 16611805
OWN - NLM
STAT- MEDLINE
DCOM- 20060502
LR  - 20211020
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 26
IP  - 15
DP  - 2006 Apr 12
TI  - Brain-derived neurotrophic factor is critically involved in 
      thermal-experience-dependent developmental plasticity.
PG  - 3899-907
AB  - All species exhibit critical period for sensory development, yet very little is 
      known about the molecules involved in the changes in the network wiring that 
      underlies this process. Here the role of brain-derived neurotrophic factor (BDNF) 
      in the critical period of thermal control establishment in chicks was 
      investigated. Neuroanatomically, the body temperature is balanced by the preoptic 
      anterior hypothalamus (PO/AH) and controlled by thermosensitive neurons. Exposure 
      to hot or cold conditions during the critical period of temperature control 
      development causes a plastic change in the ratio between heat- and cold-sensitive 
      cells and can modulate temperature tolerance. It was found that expression of 
      BDNF mRNA but not of NGF or neurotrophin-3 was induced in the PO/AH of 3-d-old 
      chicks during both heat and cold exposure. The peak of BDNF induction in both 
      heat and cold exposure occurred after 6 h, with, respectively, threefold and 
      sevenfold increases in its mRNA expression. To prove the concept that BDNF 
      activation is a critical step in thermal-experience-dependent plasticity, BDNF 
      was "knocked down" using antisense. It was found that, when BDNF in the PO/AH was 
      inhibited by 80% during the third postnatal day, thermal establishment was 
      impaired, and, after 1 week, the chicks' body temperature was reduced by 0.5 
      degrees C. Furthermore, later in life, their reaction to thermal challenge was 
      altered, and they exhibited a pronounced reduction in their ability to maintain 
      their body temperature and body weight under harsh conditions. Together, these 
      results prove that BDNF is critically involved in thermal-experience-dependent 
      development.
FAU - Katz, Adi
AU  - Katz A
AD  - Institute of Animal Science, Agricultural Research Organization, Volcani Center, 
      Bet Dagan 50250, Israel.
FAU - Meiri, Noam
AU  - Meiri N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DNA Primers)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Body Temperature
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Chickens
MH  - Cloning, Molecular
MH  - Conditioning, Psychological
MH  - DNA Primers
MH  - Gene Expression
MH  - *Hot Temperature
MH  - Male
MH  - Nerve Growth Factors/physiology
MH  - Neuronal Plasticity/*physiology
MH  - Perception
MH  - Preoptic Area/physiology
MH  - RNA, Messenger/*genetics/isolation & purification
MH  - Reverse Transcriptase Polymerase Chain Reaction
PMC - PMC6673892
EDAT- 2006/04/14 09:00
MHDA- 2006/05/04 09:00
PMCR- 2006/10/12
CRDT- 2006/04/14 09:00
PHST- 2006/04/14 09:00 [pubmed]
PHST- 2006/05/04 09:00 [medline]
PHST- 2006/04/14 09:00 [entrez]
PHST- 2006/10/12 00:00 [pmc-release]
AID - 26/15/3899 [pii]
AID - 10.1523/JNEUROSCI.0371-06.2006 [doi]
PST - ppublish
SO  - J Neurosci. 2006 Apr 12;26(15):3899-907. doi: 10.1523/JNEUROSCI.0371-06.2006.