PMID- 16612973
OWN - NLM
STAT- MEDLINE
DCOM- 20060522
LR  - 20060414
IS  - 1122-9497 (Print)
IS  - 1122-9497 (Linking)
VI  - 37
IP  - 3-4
DP  - 2005 Nov
TI  - 'Round head' sperm defect. Ultrastructural and meiotic segregation study.
PG  - 297-303
AB  - The sperm 'round head' defect, also known as globozoospermia, is an uncommon 
      alteration of sperm morphology generally characterised by 100% round headed sperm 
      totally lacking an acrosome. This alteration is a genetic sperm defect as 
      demonstrated by analysing the incidence of these alterations in a population of 
      infertile men showing a history of consanguinity and cases belonging to the same 
      family. Ultrastructural characteristics and meiotic segregation in spermatozoa 
      from two patients affected by 'round head' sperm defect were investigated. The 
      sperm quality was examined by light and transmission electron microscopy (TEM) 
      and fluorescence in situ hybridization (FISH) analysis was performed in order to 
      investigate the meiotic behavior of chromosomes namely gonosomes and chromosome 
      18. TEM analysis, mathematically elaborated, clearly diagnosed the 'round head' 
      genetic sperm defect and highlighted at the same time the presence of other 
      phenotypic alterations belonging to pathologies such as immaturity, apoptosis and 
      necrosis. It is possible to hypothesize that round headed sperm could be a 'weak 
      phenotype' allowing the sperm pathologies to overlap with a sperm defect of 
      genetic origin, further compromising fertilizing potential. FISH analysis 
      revealed a positive correlation between globozoospermia and higher disomies of 
      sex chromosomes and diploidies suggesting a higher risk of creating an aneuploid 
      embryo after intracytoplasmic sperm injection.
FAU - Moretti, E
AU  - Moretti E
AD  - Department of Pediatrics, Obstetrics and Reproductive Medicine, Biology Section, 
      University of Siena, Regional Referral Center for Male Infertility, Siena 
      University General Hospital, Italy.
FAU - Collodel, G
AU  - Collodel G
FAU - Scapigliati, G
AU  - Scapigliati G
FAU - Cosci, I
AU  - Cosci I
FAU - Sartini, B
AU  - Sartini B
FAU - Baccetti, B
AU  - Baccetti B
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Italy
TA  - J Submicrosc Cytol Pathol
JT  - Journal of submicroscopic cytology and pathology
JID - 8804312
SB  - IM
MH  - Adult
MH  - Aneuploidy
MH  - Chromosomes, Human, Pair 18/*genetics
MH  - Chromosomes, Human, Y/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/*etiology
MH  - Male
MH  - Meiosis/*genetics
MH  - Microscopy, Electron, Transmission
MH  - *Sex Chromosome Aberrations
MH  - Sperm Head/ultrastructure
MH  - Spermatozoa/*ultrastructure
EDAT- 2006/04/15 09:00
MHDA- 2006/05/23 09:00
CRDT- 2006/04/15 09:00
PHST- 2006/04/15 09:00 [pubmed]
PHST- 2006/05/23 09:00 [medline]
PHST- 2006/04/15 09:00 [entrez]
PST - ppublish
SO  - J Submicrosc Cytol Pathol. 2005 Nov;37(3-4):297-303.