PMID- 16614246
OWN - NLM
STAT- MEDLINE
DCOM- 20061005
LR  - 20211020
IS  - 0006-4971 (Print)
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 108
IP  - 3
DP  - 2006 Aug 1
TI  - The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human 
      dendritic-cell immunostimulatory function.
PG  - 947-55
AB  - Dendritic cells (DCs) that capture apoptotic cells (ACs) in the steady state 
      mediate peripheral tolerance to self-antigens. ACs are recognized by an array of 
      receptors on DCs, the redundancy of which is not completely defined. We made use 
      of an AC surrogate system to address the individual roles of the alphavbeta5 and 
      complement receptors (CRs) in the phagocytosis and induction of immunity. CR3 and 
      CR4, while substantially less efficient than alphavbeta5 in internalizing ACs, 
      initiate signals that render DCs tolerogenic. Responding T cells show impaired 
      proliferation and IFNgamma production and subsequently die by apoptosis. While 
      tolerogenic DCs are not induced via alphavbeta5, coligation of CR3 and 
      alphavbeta5 maintains the DC's tolerogenic profile. This immunomodulatory role, 
      however, is countered by a significant inflammatory stimulus such as bacterial 
      infection. Overall, our data suggest that under steady-state conditions, 
      signaling via CRs predominates to render DCs tolerogenic.
FAU - Skoberne, Mojca
AU  - Skoberne M
AD  - New York University School of Medicine, 550 First Ave, MSB 507, New York, NY 
      10016, USA.
FAU - Somersan, Selin
AU  - Somersan S
FAU - Almodovar, Wanda
AU  - Almodovar W
FAU - Truong, Tuan
AU  - Truong T
FAU - Petrova, Kseniya
AU  - Petrova K
FAU - Henson, Peter M
AU  - Henson PM
FAU - Bhardwaj, Nina
AU  - Bhardwaj N
LA  - eng
GR  - AI44628/AI/NIAID NIH HHS/United States
GR  - CA84512/CA/NCI NIH HHS/United States
GR  - GM61031/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060413
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Integrin alphaXbeta2)
RN  - 0 (Integrins)
RN  - 0 (Macrophage-1 Antigen)
RN  - 0 (Receptors, Vitronectin)
RN  - 0 (integrin alphaVbeta5)
SB  - IM
MH  - Apoptosis/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Integrin alphaXbeta2/immunology/physiology
MH  - Integrins/immunology/*physiology
MH  - Macrophage-1 Antigen/immunology/*physiology
MH  - Phagocytosis/immunology
MH  - Receptors, Vitronectin/immunology/*physiology
MH  - Self Tolerance/immunology
MH  - T-Lymphocytes/immunology
PMC - PMC1895855
EDAT- 2006/04/15 09:00
MHDA- 2006/10/06 09:00
PMCR- 2007/08/01
CRDT- 2006/04/15 09:00
PHST- 2006/04/15 09:00 [pubmed]
PHST- 2006/10/06 09:00 [medline]
PHST- 2006/04/15 09:00 [entrez]
PHST- 2007/08/01 00:00 [pmc-release]
AID - S0006-4971(20)52748-1 [pii]
AID - 0947 [pii]
AID - 10.1182/blood-2005-12-4812 [doi]
PST - ppublish
SO  - Blood. 2006 Aug 1;108(3):947-55. doi: 10.1182/blood-2005-12-4812. Epub 2006 Apr 
      13.