PMID- 16614511
OWN - NLM
STAT- MEDLINE
DCOM- 20060630
LR  - 20211020
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 21
IP  - 2
DP  - 2006 Apr
TI  - Clinical characteristics and outcomes of posttransplant lymphoproliferative 
      disorders following allogeneic hematopoietic stem cell transplantation in Korea.
PG  - 259-64
AB  - Between 1995 and 2003, seven cases of posttransplant lymphoproliferative disorder 
      (PTLD) were identified among 1,116 patients who received allogeneic hematopoietic 
      stem cell transplantations (HSCT) at Catholic HSCT Center (overall incidence 
      0.6%). Five (71.4%) patients had episodes of acute graft-versus-host-disease 
      (GVHD) and were treated with steroids. Cervical lymphadenopathy was observed in 
      most cases (71.4%), but clinical symptoms varied depending on the involved sites. 
      Pathologic findings varied: 1 case of plasmacytic hyperplasia, 3 of polymorphic 
      PTLD, 2 of diffuse large B-cell lymphoma, 1 of large T-cell lymphoma, which 
      proved to be associated with Epstein-Barr virus (EBV). The proportion of 
      EBV-negative PTLD was 33.3%. Five patients demonstrated a good response to 
      treatment (treatment response rate 71.4%). The overall mortality was 42.8%, and 
      one death was directly attributable to PTLD. The incidence of PTLD is expected to 
      increase, based on the rising use of grafts from alternative donors and recent 
      clinical features of PTLD manifested by a disseminated and fulminant nature. It 
      is necessary to have a high level of suspicion when monitoring patients and 
      readily adopt prompt and effective cellular immunotherapy for PTLD.
FAU - Park, Sun Hee
AU  - Park SH
AD  - Department of Internal Medicine, The Catholic Hematopoietic Stem Cell 
      Transplantation Center, The Catholic University of Korea, College of Medicine, 
      Seoul, Korea.
FAU - Choi, Su Mi
AU  - Choi SM
FAU - Lee, Dong Gun
AU  - Lee DG
FAU - Choi, Jung Hyun
AU  - Choi JH
FAU - Yoo, Jin Hong
AU  - Yoo JH
FAU - Kim, Hee Je
AU  - Kim HJ
FAU - Kim, Dong Wook
AU  - Kim DW
FAU - Lee, Jong Wook
AU  - Lee JW
FAU - Min, Woo Sung
AU  - Min WS
FAU - Shin, Wan Shik
AU  - Shin WS
FAU - Kim, Chun Choo
AU  - Kim CC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Epstein-Barr Virus Infections/etiology
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Korea
MH  - Lymphoma, B-Cell/etiology
MH  - Lymphoma, Large B-Cell, Diffuse/etiology
MH  - Lymphoma, T-Cell/etiology
MH  - Lymphoproliferative Disorders/*etiology/pathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Transplantation, Homologous
PMC - PMC2734001
EDAT- 2006/04/15 09:00
MHDA- 2006/07/01 09:00
PMCR- 2006/04/01
CRDT- 2006/04/15 09:00
PHST- 2006/04/15 09:00 [pubmed]
PHST- 2006/07/01 09:00 [medline]
PHST- 2006/04/15 09:00 [entrez]
PHST- 2006/04/01 00:00 [pmc-release]
AID - 200604259 [pii]
AID - 10.3346/jkms.2006.21.2.259 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2006 Apr;21(2):259-64. doi: 10.3346/jkms.2006.21.2.259.