PMID- 16614715
OWN - NLM
STAT- MEDLINE
DCOM- 20060524
LR  - 20220224
IS  - 1812-9269 (Print)
IS  - 1812-9269 (Linking)
VI  - 28
IP  - 1
DP  - 2006 Mar
TI  - The clinical significance of soluble E-cadherin in nonsmall cell lung cancer.
PG  - 83-5
AB  - AIM: Aberrant expression of the epithelial transmembrane adhesion molecule 
      E-cadherin (E-cad) has been associated with many human malignancies. In the 
      present study the clinical significance of serum levels of soluble E-cadherin 
      (sE-cad) in newly diagnosed patients with non small cell lung cancer (NSCLC) was 
      investigated. MATERIAL AND METHODS: An enzyme linked immunospecific assay (ELISA) 
      to determine the circulating levels of sE-cad in 20 newly diagnosed patients with 
      NSCLC as well as in 29 healthy volunteers (control group) was used. RESULTS: 
      NSCLC patients exerted increased circulating levels of sE-cad compared with 
      individuals of the control group (p < 0.001). An association was also detected 
      between serum sE-cad levels and the development of distant metastases. On the 
      contrary, no statistically significant correlation could be established with 
      histological type, gender and smoking habits. Patients with increased sE-cad 
      levels at diagnosis had worser outcome, although multivariate analysis failed to 
      demonstrate that sE-cad levels represent an independent prognostic factor of 
      survival. CONCLUSION: Our data suggest that E-cad plays a role in the 
      pathogenesis of NSCLC. sE-cad levels may be further studied as a potential 
      prognostic biomarker.
FAU - Charalabopoulos, K
AU  - Charalabopoulos K
AD  - Department of Physiology, Clinical Unit, Ioannina University Medical Faculty, 
      Greece. kcharala@cc.uoi.gr
FAU - Gogali, A
AU  - Gogali A
FAU - Dalavaga, Y
AU  - Dalavaga Y
FAU - Daskalopoulos, G
AU  - Daskalopoulos G
FAU - Vassiliou, M
AU  - Vassiliou M
FAU - Bablekos, G
AU  - Bablekos G
FAU - Karakosta, A
AU  - Karakosta A
FAU - Constantopoulos, S
AU  - Constantopoulos S
LA  - eng
PT  - Journal Article
PL  - Ukraine
TA  - Exp Oncol
JT  - Experimental oncology
JID - 101230541
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cadherins)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/blood
MH  - Cadherins/*blood
MH  - Carcinoma, Non-Small-Cell Lung/*pathology
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Smoking
EDAT- 2006/04/15 09:00
MHDA- 2006/05/25 09:00
CRDT- 2006/04/15 09:00
PHST- 2006/04/15 09:00 [pubmed]
PHST- 2006/05/25 09:00 [medline]
PHST- 2006/04/15 09:00 [entrez]
AID - 25/502 [pii]
PST - ppublish
SO  - Exp Oncol. 2006 Mar;28(1):83-5.