PMID- 16615154
OWN - NLM
STAT- MEDLINE
DCOM- 20060523
LR  - 20061115
IS  - 0022-4790 (Print)
IS  - 0022-4790 (Linking)
VI  - 93
IP  - 6
DP  - 2006 May 1
TI  - The changes of estrogen receptor-beta variants expression in breast 
      carcinogenesis: Decrease of estrogen receptor-beta2 expression is the key event 
      in breast cancer development.
PG  - 504-10
AB  - BACKGROUND AND OBJECTIVES: Although more than five variant forms of estrogen 
      receptor-beta (ERbeta) have been identified, their role has not been identified. 
      This study was carried out to investigate the changes of ERbeta variants in 
      breast cancer development. METHODS: Using reverse transcription polymerase chain 
      reaction (RT-PCR) and triple primer PCR (TP-PCR), the expression levels of ERbeta 
      variants mRNA were measured in 66 paired normal and cancer tissues. The relative 
      expression level of ERbeta variants were compared between normal and cancer 
      tissues, and also compared according to various clinicopathological parameters. 
      RESULTS: Among ERbeta variants, ERbeta2 and ERbeta5 consist of the major 
      proportion of ERbeta expression both in normal and cancer tissues. The ERbeta and 
      ERbeta2 expression levels decreased significantly in the cancers compared with 
      corresponding normal tissues, particularly in ERalpha-expressing cancers. 
      However, ERbeta5 expression level increased significantly in the cancers, 
      especially in those of postmenopausal patients. The relative increase of ERbeta5 
      expression in cancer tissues was associated with favorable differentiation. 
      CONCLUSIONS: Decrease of ERbeta2 is thought to be the key reason for the decrease 
      in ERbeta expression in cancer tissues, and it is particularly associated with 
      the development of ERalpha-expressing breast cancer.
CI  - Copyright 2006 Wiley-Liss, Inc.
FAU - Park, Byeong-Woo
AU  - Park BW
AD  - Department of Surgery, Yonsei University College of Medicine, Seodaemun-ku, 
      Seoul, Korea. bwpark@yumc.yonsei.ac.kr
FAU - Kim, Ki-Suk
AU  - Kim KS
FAU - Heo, Min-Kyu
AU  - Heo MK
FAU - Yang, Woo-Ick
AU  - Yang WI
FAU - Kim, Seung Il
AU  - Kim SI
FAU - Kim, Joo-Hang
AU  - Kim JH
FAU - Kim, Gwi Eon
AU  - Kim GE
FAU - Lee, Kyong Sik
AU  - Lee KS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Surg Oncol
JT  - Journal of surgical oncology
JID - 0222643
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Neoplasm)
SB  - IM
MH  - Breast/metabolism
MH  - Breast Neoplasms/*etiology/genetics/*metabolism/pathology
MH  - Estrogen Receptor alpha/metabolism
MH  - Estrogen Receptor beta/genetics/*metabolism/physiology
MH  - Female
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - Postmenopause/metabolism
MH  - Premenopause/metabolism
MH  - RNA Splicing/genetics
MH  - RNA, Messenger/biosynthesis
MH  - RNA, Neoplasm/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2006/04/15 09:00
MHDA- 2006/05/24 09:00
CRDT- 2006/04/15 09:00
PHST- 2006/04/15 09:00 [pubmed]
PHST- 2006/05/24 09:00 [medline]
PHST- 2006/04/15 09:00 [entrez]
AID - 10.1002/jso.20336 [doi]
PST - ppublish
SO  - J Surg Oncol. 2006 May 1;93(6):504-10. doi: 10.1002/jso.20336.