PMID- 1661622
OWN - NLM
STAT- MEDLINE
DCOM- 19920204
LR  - 20211203
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 2
IP  - 10
DP  - 1991 Oct
TI  - Messenger RNAs for trk and the low-affinity NGF receptor in rat basal forebrain.
PG  - 593-6
AB  - Nerve growth factor (NGF) acts by binding to specific sets of neurons. 
      Low-affinity binding (Kd of 10(-9) M) is mediated via a 75 kDa glycoprotein 
      (LNGFR). Recently, a 140 kDa tyrosine protein kinase encoded by the 
      proto-oncogene trk has been found to bind NGF with high affinity (Kd of 10(-11) 
      M) and to evoke neurotrophic responses. In addition, the related trkB protein and 
      the LNGFR have been shown to bind brain-derived neurotrophic factor (BDNF) and 
      neurotrophin-3 (NT-3) with an affinity of Kd 10(-9) M. We demonstrate the 
      distribution of mRNA encoding the neurotrophin-binding proteins in the forebrain 
      of the 21-day-old Sprague-Dawley rat by in-situ hybridization. Expression of trk 
      and LNGFR mRNA showed co-localization and was restricted to the medial septal 
      nucleus and the nucleus of Broca's diagonal band, suggesting a receptor function 
      in these cells for both proteins encoded. In contrast, expression of trkB was 
      widely spread in many areas. Thus trkB protein might serve general functions in 
      the forebrain.
FAU - Vazquez, M E
AU  - Vazquez ME
AD  - Department of Developmental Biology, Uppsala University, Sweden.
FAU - Ebendal, T
AU  - Ebendal T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (MAS1 protein, human)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (Oncogene Proteins)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (oncogene protein trk)
RN  - 9007-49-2 (DNA)
SB  - IM
GS  - trk
GS  - trkB
MH  - Aging
MH  - Animals
MH  - Base Sequence
MH  - DNA/genetics
MH  - Humans
MH  - Membrane Glycoproteins/*genetics
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/metabolism
MH  - Nucleic Acid Hybridization
MH  - Oligodeoxyribonucleotides/chemical synthesis
MH  - Oligonucleotides, Antisense/chemical synthesis
MH  - Oncogene Proteins/*genetics
MH  - *Oncogenes
MH  - Prosencephalon/cytology/growth & development/*physiology
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogenes
MH  - RNA, Messenger/analysis/*genetics
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Cell Surface/*genetics/metabolism
MH  - Receptors, Nerve Growth Factor
EDAT- 1991/10/01 00:00
MHDA- 1991/10/01 00:01
CRDT- 1991/10/01 00:00
PHST- 1991/10/01 00:00 [pubmed]
PHST- 1991/10/01 00:01 [medline]
PHST- 1991/10/01 00:00 [entrez]
AID - 10.1097/00001756-199110000-00010 [doi]
PST - ppublish
SO  - Neuroreport. 1991 Oct;2(10):593-6. doi: 10.1097/00001756-199110000-00010.