PMID- 16616783
OWN - NLM
STAT- MEDLINE
DCOM- 20070228
LR  - 20111117
IS  - 1532-2742 (Electronic)
IS  - 0163-4453 (Linking)
VI  - 54
IP  - 2
DP  - 2007 Feb
TI  - Clinical significance and epidemiology of non-pigmented rapidly growing 
      mycobacteria in a university hospital.
PG  - 135-45
AB  - OBJECTIVES: To study the clinical significance and epidemiology of Non-pigmented 
      rapidly growing mycobacteria (NPRGM) during a 13-year period. METHODS: We 
      performed a retrospective study of patients with isolates of NPRGM to evaluate 
      their clinical significance. We also analyzed the strains using Randomly 
      Amplified Polymorphic DNA (RAPD) analysis to evaluate the relationship between 
      strains. RESULTS: Between 1990 and 2003, 65 patients had an isolate of NPRGM. 
      Twenty of them were considered significant (19 cases) or doubtful (1 case). Many 
      cases were skin and soft tissue infections. Six cases were foreign-body related. 
      All the patients recovered with antibiotic therapy and removal of the foreign 
      body. All the patients were apparently unrelated, despite 56.9% of the isolates 
      were detected between 1995 and 1997. RAPD analysis was performed on 43 strains, 
      and showed only a cluster of two Mycobacterium chelonae isolates. Both of them 
      were related with contamination of a laboratory reactive, and were considered 
      non-significant. CONCLUSION: In our hospital, almost one-third of the isolates of 
      NPRGM were significant, being this percentage higher for skin and soft tissue 
      isolates. Patients were cured with antibiotic therapy, but the removal of foreign 
      bodies appeared to be necessary for a good outcome. A minor pseudo-outbreak was 
      detected. No predominant strain was detected.
FAU - Esteban, J
AU  - Esteban J
AD  - Department of Clinical Microbiology, Fundacion Jimenez Diaz, Av. Reyes Catolicos 
      2, 28040-Madrid, Spain. jesteban@fjd.es
FAU - Fernandez Roblas, R
AU  - Fernandez Roblas R
FAU - Garcia Cia, J I
AU  - Garcia Cia JI
FAU - Zamora, N
AU  - Zamora N
FAU - Ortiz, A
AU  - Ortiz A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060417
PL  - England
TA  - J Infect
JT  - The Journal of infection
JID - 7908424
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - *Hospitals, University
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Molecular Epidemiology
MH  - Mycobacterium Infections, 
      Nontuberculous/*epidemiology/microbiology/*physiopathology
MH  - Nontuberculous Mycobacteria/*classification/*genetics/isolation & 
      purification/pathogenicity
MH  - Polymerase Chain Reaction
MH  - Random Amplified Polymorphic DNA Technique
MH  - Skin Diseases, Bacterial/epidemiology/microbiology
MH  - Soft Tissue Infections/epidemiology/microbiology
MH  - Spain/epidemiology
EDAT- 2006/04/18 09:00
MHDA- 2007/03/01 09:00
CRDT- 2006/04/18 09:00
PHST- 2005/11/10 00:00 [received]
PHST- 2006/02/21 00:00 [revised]
PHST- 2006/02/23 00:00 [accepted]
PHST- 2006/04/18 09:00 [pubmed]
PHST- 2007/03/01 09:00 [medline]
PHST- 2006/04/18 09:00 [entrez]
AID - S0163-4453(06)00071-5 [pii]
AID - 10.1016/j.jinf.2006.02.017 [doi]
PST - ppublish
SO  - J Infect. 2007 Feb;54(2):135-45. doi: 10.1016/j.jinf.2006.02.017. Epub 2006 Apr 
      17.