PMID- 16617255
OWN - NLM
STAT- MEDLINE
DCOM- 20060522
LR  - 20201209
IS  - 0090-3493 (Print)
IS  - 0090-3493 (Linking)
VI  - 34
IP  - 5 Suppl
DP  - 2006 May
TI  - Mechanisms of transfusion-related acute lung injury (TRALI): anti-leukocyte 
      antibodies.
PG  - S118-23
AB  - There is abundant evidence that leukocyte antibodies in blood donor products are 
      somehow involved in transfusion-related acute lung injury (TRALI). Human 
      leukocyte antigen (HLA) class I, HLA class II, and neutrophil-specific antibodies 
      in the plasma of both blood donors and recipients have been implicated in the 
      pathogenesis of TRALI. The case for a relationship between leukocyte antibodies 
      and TRALI is more compelling if concordance between the antigen specificity of 
      the leukocyte antibodies in the donor plasma and the corresponding antigen on the 
      cells of the affected recipient is demonstrated. Such antibody-antigen 
      concordance can be investigated by typing the recipient for the cognate leukocyte 
      antigens or by cross-matching the donor plasma against the recipient's 
      leukocytes. Two proposed pathophysiologic mechanisms for TRALI have received the 
      most attention: the antibody hypothesis and the two-event hypothesis. The final 
      common pathway in all of the proposed pathogenic mechanisms of TRALI is increased 
      pulmonary capillary permeability, which results in movement of plasma into the 
      alveolar space causing pulmonary edema. A typical TRALI serologic workup consists 
      of tests for HLA class I and II and neutrophil-specific antibodies. The use of 
      flow cytometry and HLA-coated microbeads is recommended for detection of HLA 
      antibodies in plasma of implicated blood donors and a combination of the 
      granulocyte agglutination test and granulocyte immunofluorescence test for 
      detection of neutrophil-specific antibodies. Genotyping for class I and II HLA 
      and for a limited number of neutrophil antigens may also be helpful in 
      establishing antibody-antigen concordance.
FAU - Curtis, Brian R
AU  - Curtis BR
AD  - Platelet & Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, 
      WI, USA.
FAU - McFarland, Janice G
AU  - McFarland JG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Antigen-Antibody Reactions
MH  - Blood Donors
MH  - Blood Grouping and Crossmatching
MH  - Histocompatibility Antigens Class I/immunology
MH  - Histocompatibility Antigens Class II/immunology
MH  - Humans
MH  - Isoantibodies/blood/*immunology
MH  - Leukocytes/*immunology
MH  - Neutrophils/immunology
MH  - Respiratory Distress Syndrome/*etiology/*immunology
MH  - *Transfusion Reaction
RF  - 55
EDAT- 2006/04/18 09:00
MHDA- 2006/05/23 09:00
CRDT- 2006/04/18 09:00
PHST- 2006/04/18 09:00 [pubmed]
PHST- 2006/05/23 09:00 [medline]
PHST- 2006/04/18 09:00 [entrez]
AID - 00003246-200605001-00006 [pii]
AID - 10.1097/01.CCM.0000214293.72918.D8 [doi]
PST - ppublish
SO  - Crit Care Med. 2006 May;34(5 Suppl):S118-23. doi: 
      10.1097/01.CCM.0000214293.72918.D8.