PMID- 16617930
OWN - NLM
STAT- MEDLINE
DCOM- 20060504
LR  - 20220408
IS  - 1053-0894 (Print)
IS  - 1053-0894 (Linking)
VI  - 16
IP  - 4
DP  - 2006 Apr
TI  - Immune reconstitution inflammatory syndromes: what's new?
PG  - 199-206, 213, 216-217; discussion 214-7
AB  - The immune reconstitution inflammatory syndrome (IRIS) is characterized by 
      worsening clinical, laboratory, or radiologic findings despite improvements in 
      the HIV RNA level and CD4 count after the introduction of antiretroviral therapy 
      and is due to the restoration of pathogen-specific immune responses. IRIS may 
      occur during or shortly after the treatment of an opportunistic infection or as a 
      "new" clinical syndrome resulting from a previously unrecognized occult 
      infection. Risk factors for IRIS include a low CD4 count, the presence of latent 
      infection(s), and a robust virologic and immunologic response to HAART. In 
      addition to infectious pathogens, IRIS is associated with autoimmune or 
      malignancy-related conditions. Given the increasing availability of HAART, the 
      number and types of IRIS encountered by HIV care providers will also increase. 
      The prognosis for most IRIS cases is favorable because a robust inflammatory 
      response may predict an excellent response to HAART in terms of immune 
      reconstitution and, perhaps, improved survival. This article summarizes the 
      various clinical presentations of IRIS and discusses the diagnosis and treatment 
      of these immune-related syndromes.
FAU - Crum-Cianflone, Nancy F
AU  - Crum-Cianflone NF
AD  - TriService AIDS Clinical Consortium, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - AIDS Read
JT  - The AIDS reader
JID - 9206753
SB  - IM
MH  - AIDS-Related Opportunistic Infections/chemically 
      induced/*complications/immunology
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - Inflammation/*chemically induced/immunology/physiopathology
MH  - Syndrome
RF  - 114
EDAT- 2006/04/19 09:00
MHDA- 2006/05/05 09:00
CRDT- 2006/04/19 09:00
PHST- 2006/04/19 09:00 [pubmed]
PHST- 2006/05/05 09:00 [medline]
PHST- 2006/04/19 09:00 [entrez]
PST - ppublish
SO  - AIDS Read. 2006 Apr;16(4):199-206, 213, 216-217; discussion 214-7.