PMID- 16618241
OWN - NLM
STAT- MEDLINE
DCOM- 20060516
LR  - 20220408
IS  - 0025-729X (Print)
IS  - 0025-729X (Linking)
VI  - 184
IP  - 8
DP  - 2006 Apr 17
TI  - No longer a biological waste product: umbilical cord blood.
PG  - 407-10
AB  - Haematopoietic stem cell transplantation is an accepted curative therapy for many 
      cancers and inherited non-malignant diseases, including bone marrow failure 
      syndromes, haemoglobinopathies, and inborn errors of metabolism. Stem cells can 
      be used from the bone marrow or blood of matched siblings or appropriately 
      matched unrelated volunteers, but many patients do not have a suitably matched 
      donor. Umbilical cord blood (UCB) has been successfully used as an alternative 
      stem cell source. It has the advantage of tolerance for a degree of human 
      leukocyte antigen (HLA) incompatibility not possible with adult bone marrow, 
      resulting in greater likelihood of finding an appropriate match. UCB is also 
      stored fully tested and cryopreserved, leading to rapid availability. Greatest 
      clinical experience in UCB transplants has been in treating paediatric leukaemia. 
      Results using well matched UCB grafts are equivalent or better than with 
      unrelated bone marrow transplant. Cell dose and the degree of HLA matching are 
      critical determinants in the success of UCB transplant. The use of UCB in older 
      children and adult patients has been limited by the fixed, low cell dose 
      available in a UCB unit, relative to recipient weight. This can be overcome by 
      strategies such as using two or more UCB units. Early animal studies suggest that 
      UCB may have the potential to differentiate into other cell types, including 
      nervous tissue, and may in future play a role in the treatment of disorders such 
      as Alzheimer disease and Parkinson disease.
FAU - O'Brien, Tracey A
AU  - O'Brien TA
AD  - Cord Blood and Marrow Transplant Program, Centre for Children's Cancer and Blood 
      Disorders, Sydney Children's Hospital, Sydney, NSW, Australia. 
      tracey.obrien@sesiahs.health.nsw.gov.au
FAU - Tiedemann, Karin
AU  - Tiedemann K
FAU - Vowels, Marcus R
AU  - Vowels MR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Adult
MH  - Blood Donors
MH  - Child
MH  - Cord Blood Stem Cell Transplantation/*trends
MH  - Fetal Blood/physiology
MH  - Humans
MH  - Risk Assessment
MH  - Treatment Outcome
RF  - 28
EDAT- 2006/04/19 09:00
MHDA- 2006/05/17 09:00
CRDT- 2006/04/19 09:00
PHST- 2005/07/18 00:00 [received]
PHST- 2006/03/02 00:00 [accepted]
PHST- 2006/04/19 09:00 [pubmed]
PHST- 2006/05/17 09:00 [medline]
PHST- 2006/04/19 09:00 [entrez]
AID - obr10569_fm [pii]
AID - 10.5694/j.1326-5377.2006.tb00292.x [doi]
PST - ppublish
SO  - Med J Aust. 2006 Apr 17;184(8):407-10. doi: 10.5694/j.1326-5377.2006.tb00292.x.