PMID- 16618338
OWN - NLM
STAT- MEDLINE
DCOM- 20060602
LR  - 20151113
IS  - 1351-5101 (Print)
IS  - 1351-5101 (Linking)
VI  - 13
IP  - 3
DP  - 2006 Mar
TI  - Neurological complications in AIDS patients receiving HAART: a 2-year 
      retrospective study.
PG  - 233-9
AB  - The positive role of highly active anti-retroviral therapy (HAART) in reducing 
      opportunistic infections in acquired immunodeficiency syndrome (AIDS) patients is 
      well known. However, case reports from around the world have demonstrated that 
      some patients seem to suffer a paradoxical deterioration of health as their 
      immune function improves with treatment. This phenomenon has been called immune 
      restoration inflammatory syndrome (IRIS). In northern Thailand, GPO-vir 
      (Stavudine-D4T + Lamivudine-3TC + Nevirapine-NVP) has been promoted for the 
      treatment of AIDS patients since April 2002, in accordance with the Government 
      Pharmaceutical Organization's guidelines. However, the incidence rates of IRIS 
      affecting nervous system (NIRIS) and non-NIRIS in comparison with the previous 
      incidence of AIDS-defining disease have not been reported. We conducted a 
      retrospective study to review the incidence of NIRIS and non-NIRIS in AIDS 
      patients treated with GPO-vir in Chiang Mai University Hospital, Thailand, 
      between May 2002 and April 2004. We compare these incidence rates with the 
      incidence rates of neurological complications in the pre-HAART era. Altogether 
      506 AIDS patients were treated with GPO-vir during the specified period. The 
      overall incidence of NIRIS, including progressive multifocal leukoencephalopathy 
      (PML), cerebral toxoplasmosis and cytomegalovirus (CMV) retinitis, was lower than 
      the previous incidence of AIDS-defining disease in the pre-HAART era. However, 
      the incidence of ischemic stroke, hemorrhagic stroke and primary central nervous 
      system (CNS) lymphoma had increased.
FAU - Subsai, K
AU  - Subsai K
AD  - Division of Neurology, Department of Medicine, Faculty of Medicine, Chaing Mai 
      University, Chiang Mai, Thailand. skhongsa@mail.med.cmu.ac.th
FAU - Kanoksri, S
AU  - Kanoksri S
FAU - Siwaporn, C
AU  - Siwaporn C
FAU - Helen, L
AU  - Helen L
FAU - Kanokporn, O
AU  - Kanokporn O
FAU - Wantana, P
AU  - Wantana P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*complications/drug therapy/epidemiology
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-HIV Agents/*adverse effects
MH  - Antiretroviral Therapy, Highly Active/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/epidemiology/*etiology/pathology
MH  - Retrospective Studies
MH  - Thailand/epidemiology
MH  - Tomography, X-Ray Computed/methods
EDAT- 2006/04/19 09:00
MHDA- 2006/06/03 09:00
CRDT- 2006/04/19 09:00
PHST- 2006/04/19 09:00 [pubmed]
PHST- 2006/06/03 09:00 [medline]
PHST- 2006/04/19 09:00 [entrez]
AID - ENE1178 [pii]
AID - 10.1111/j.1468-1331.2006.01178.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2006 Mar;13(3):233-9. doi: 10.1111/j.1468-1331.2006.01178.x.