PMID- 16618361
OWN - NLM
STAT- MEDLINE
DCOM- 20070326
LR  - 20211020
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 17
IP  - 2
DP  - 2006 Mar
TI  - The predictive value of early life total immunoglobulin E measurement in 
      identifying atopic children in a population-based birth cohort study.
PG  - 118-24
AB  - Atopy is common and the prevalence amongst children is rising. Measurements in 
      early childhood that can predict subsequent development of atopy could be 
      clinically useful for targeting preventive measures. We used the Children in 
      Focus (CiF) subgroup of a large population-based birth cohort study (the Avon 
      Longitudinal Study of Parents and Children) to investigate whether total 
      immunoglobulin E (IgE) measured at 12 and 18 months could predict subsequent 
      development of atopy at 5 yr of age. Atopy was determined by positive skin prick 
      test (> or = 3 mm wheal) to one or more of 14 inhalant and food allergens. 
      Prevalence of skin prick positivity to any allergen was 14.5% (104 of 715; 95% 
      CI: 12.0-17.1%). Total IgE levels were significantly higher at 12 months of age 
      (p < 0.0005) but not 18 months of age in those children subsequently atopic. The 
      highest positive predictive value was 41% with an IgE measurement of >51 kU/l, 
      with a sensitivity of 13.5% and a specificity of 95.8%. Although significant 
      differences in early life IgE measurements were seen, the extent of overlap was 
      great, such that the overall performance of IgE at 12 months as a screening test 
      for atopy was poor.
FAU - Perkin, Michael R
AU  - Perkin MR
AD  - Department of Child Health, St George's, University of London, London, UK. 
      m.perkin@sgul.ac.uk
FAU - Strachan, David P
AU  - Strachan DP
FAU - Williams, H C
AU  - Williams HC
FAU - Lack, Gideon
AU  - Lack G
FAU - Golding, Jean
AU  - Golding J
CN  - ALSPAC Study Team
LA  - eng
GR  - G9815508/MRC_/Medical Research Council/United Kingdom
GR  - 056906/Z/99/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Hypersensitivity/blood/*diagnosis/immunology
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Male
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Skin Tests
EDAT- 2006/04/19 09:00
MHDA- 2007/03/27 09:00
CRDT- 2006/04/19 09:00
PHST- 2006/04/19 09:00 [pubmed]
PHST- 2007/03/27 09:00 [medline]
PHST- 2006/04/19 09:00 [entrez]
AID - PAI364 [pii]
AID - 10.1111/j.1399-3038.2005.00364.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2006 Mar;17(2):118-24. doi: 
      10.1111/j.1399-3038.2005.00364.x.