PMID- 16619492
OWN - NLM
STAT- MEDLINE
DCOM- 20060511
LR  - 20061115
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 26
IP  - 2A
DP  - 2006 Mar-Apr
TI  - Chromosome 1 abnormalities in multiple myeloma.
PG  - 953-9
AB  - Multiple myeloma (MM) is a malignancy of the terminally-differentiated B cells 
      and accounts for 10% of all hematological malignancies. Chromosome 1 aberrations 
      are frequently described, the short arm being preferentially involved in 
      deletions and the long arm in gains. The abnormalities were identified in the 
      bone marrow of 37 MM patients by conventional cytogenetics. Fluorescence in situ 
      hybridization (FISH) was used to confirm the presence of the abnormalities and to 
      better characterize them. Chromosome 1 abnormalities were grouped into 4 
      categories: balanced translocations, deletions, amplifications and jumping 
      translocations (JT). Breakpoints involved in balanced translocations were 
      randomly distributed. The smallest region of overlap for deletions was 1p11 --> 
      1p21 (present in 27% of the patients) and for gains 1q31 --> 1qter (present in 
      54% of the patients). The whole long arm was found to be the donor segment for 
      the majority of patients with JT, the most frequent recipients being chromosomes 
      16 and 19. Our results share some similarities with those obtained for 143 
      published patients studied by FISH. Band 1p21 was found to be frequently deleted, 
      leading to the assumption that a 1p deletion could lead to hemizygosity of at 
      least 1 tumor suppressor gene. Two regions of 1q showed preferential gains: q12 
      to q22 and q31 to q42; these amplifications could induce the overexpression of 1 
      or more oncogenes. In conclusion, our results confirm that chromosome 1 
      abnormalities play an important role in the pathogenesis of multiple myeloma.
FAU - Marzin, Youna
AU  - Marzin Y
AD  - Laboratoire d'Histologie, Embryologie et Cytogenetique, Faculte de Medecine et 
      des Sciences de la Sante, Universite de Bretagne Occidentale, Brest, France.
FAU - Jamet, Deborah
AU  - Jamet D
FAU - Douet-Guilbert, Nathalie
AU  - Douet-Guilbert N
FAU - Morel, Frederic
AU  - Morel F
FAU - Le Bris, Marie-Josee
AU  - Le Bris MJ
FAU - Morice, Patrick
AU  - Morice P
FAU - Abgrall, Jean-Francois
AU  - Abgrall JF
FAU - Berthou, Christian
AU  - Berthou C
FAU - De Braekeleer, Marc
AU  - De Braekeleer M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Multiple Myeloma/*genetics
MH  - Translocation, Genetic
EDAT- 2006/04/20 09:00
MHDA- 2006/05/12 09:00
CRDT- 2006/04/20 09:00
PHST- 2006/04/20 09:00 [pubmed]
PHST- 2006/05/12 09:00 [medline]
PHST- 2006/04/20 09:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2006 Mar-Apr;26(2A):953-9.