PMID- 16619539
OWN - NLM
STAT- MEDLINE
DCOM- 20060525
LR  - 20061115
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 26
IP  - 2B
DP  - 2006 Mar-Apr
TI  - A related donor and reduced intensity conditioning reduces the risk of 
      development of BK virus-positive haemorrhagic cystitis in allogeneic 
      haematopoetic stem cell-transplanted patients.
PG  - 1311-8
AB  - The significance of the BK virus (BKV) and possible co-factors for the 
      development of late onset haemorrhagic cystitis (HC) in allogeneic haematopoetic 
      stem cell (HSCT)-transplanted patients is reviewed. BKV-associated HC causes 
      significant morbidity and mortality in HSCT patients, however, BK-viruria cannot 
      distinguish patients at risk of HC, since it is observed in patients with and 
      without HC. Several studies have therefore attempted to identify co-factors for 
      the development of HC. Acute graft versus host disease was in the past, though 
      less so recently, reported to correlate to the incidence of HC. However, patients 
      who had received grafts from unrelated donors (URD) and had had full conditioning 
      prior to HSCT were shown to have an increased risk of HC, compared to patients 
      who had received HSCT from a related donor (RD) or patients who had received 
      reduced intensity conditioning. In conclusion, HSCT patients with BK-viruria, an 
      URD and receiving full conditioning have an increased risk of developing HC.
FAU - Bogdanovic, Gordana
AU  - Bogdanovic G
AD  - Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
FAU - Priftakis, Peter
AU  - Priftakis P
FAU - Giraud, Geraldine
AU  - Giraud G
FAU - Dalianis, Tina
AU  - Dalianis T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - BK Virus/genetics/*physiology
MH  - Cystitis/*etiology/genetics/*prevention & control/virology
MH  - Graft vs Host Disease/etiology/virology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects/*methods
MH  - Humans
MH  - Polyomavirus Infections/etiology/genetics/prevention & control/virology
MH  - Tissue Donors
MH  - Transplantation Conditioning/*methods
MH  - Transplantation, Homologous
MH  - Tumor Virus Infections/etiology/genetics/prevention & control/virology
RF  - 50
EDAT- 2006/04/20 09:00
MHDA- 2006/05/26 09:00
CRDT- 2006/04/20 09:00
PHST- 2006/04/20 09:00 [pubmed]
PHST- 2006/05/26 09:00 [medline]
PHST- 2006/04/20 09:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2006 Mar-Apr;26(2B):1311-8.