PMID- 16620274
OWN - NLM
STAT- MEDLINE
DCOM- 20060822
LR  - 20131121
IS  - 0742-3071 (Print)
IS  - 0742-3071 (Linking)
VI  - 23
IP  - 4
DP  - 2006 Apr
TI  - Diabetes with partial lipodystrophy following sclerodermatous chronic graft vs. 
      host disease.
PG  - 436-40
AB  - BACKGROUND: The importance of adipose tissue in metabolism, as a target for 
      insulin action and a secretor of metabolic regulatory proteins, is increasingly 
      recognized. Lipodystrophic conditions are often associated with significant 
      insulin resistance. The commonest acquired form occurs with highly active 
      antiretroviral therapy (HAART) for human immunodeficiency virus infection. Other 
      medical conditions and drugs also have the potential to cause chronic 
      subcutaneous fat damage. CASE REPORT: We describe an unfamiliar partial 
      lipodystrophy in a young woman, associated with markedly insulin-resistant 
      diabetes, acquired following allogeneic bone marrow transplantation for childhood 
      leukaemia complicated by late sclerodermatous chronic graft vs. host disease 
      (GVHD). Clinical examination revealed scarring and lipodystrophy affecting mainly 
      legs, thighs, buttocks and forearms but sparing her face, neck and thorax. Her 
      serum adiponectin level was markedly reduced. CONCLUSIONS: However, although 
      thiazolidinediones lower insulin resistance and increase subcutaneous peripheral 
      fat in Type 2 diabetes, pioglitazone treatment had little effect on either serum 
      adiponectin, glycaemic control or the lipoatrophy. In this case, effective 
      glycaemic control was best achieved using a combination of metformin and highly 
      concentrated soluble insulin injections.
FAU - Rooney, D P
AU  - Rooney DP
AD  - Department of Diabetes and Endocrinology and Biochemistry Laboratory, Antrim Area 
      Hospital, Antrim, UK. dprooney@doctors.org.uk
FAU - Ryan, M F
AU  - Ryan MF
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Adolescent
MH  - Bone Marrow Transplantation
MH  - Diabetes Mellitus, Type 2/drug therapy/*etiology
MH  - Female
MH  - *Graft vs Host Disease
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Insulin/therapeutic use
MH  - Lipodystrophy/*etiology
MH  - Metformin/therapeutic use
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy
MH  - Scleroderma, Localized/drug therapy/*etiology
MH  - Transplantation, Homologous
EDAT- 2006/04/20 09:00
MHDA- 2006/08/23 09:00
CRDT- 2006/04/20 09:00
PHST- 2006/04/20 09:00 [pubmed]
PHST- 2006/08/23 09:00 [medline]
PHST- 2006/04/20 09:00 [entrez]
AID - DME1855 [pii]
AID - 10.1111/j.1464-5491.2006.01855.x [doi]
PST - ppublish
SO  - Diabet Med. 2006 Apr;23(4):436-40. doi: 10.1111/j.1464-5491.2006.01855.x.