PMID- 16620332
OWN - NLM
STAT- MEDLINE
DCOM- 20080129
LR  - 20140729
IS  - 1749-4478 (Print)
IS  - 1749-4478 (Linking)
VI  - 31
IP  - 2
DP  - 2006 Apr
TI  - Total serum IgE and IgE antibodies specific to house dust mite found in two 
      aged-matched cohorts of children with and without otitis media with effusion.
PG  - 130-3
AB  - OBJECTIVES: To determine whether otitis media with effusion (OME) is associated 
      with elevated serum immunoglobulin E (IgE) and IgE specific for house dust mite. 
      DESIGN: Forty-seven children who had evidence of bilateral OME, both 
      otoscopically and on tympanometry, on two separate occasions, 3 months apart were 
      admitted for ventilation tubes. Forty-eight children admitted for minor eye 
      surgery who had otoscopically normal ears and no history of middle ear problems 
      were used as controls. Bloods samples were taken under anaesthesia. Total IgE and 
      IgE radioallergosorbent test (RAST) to house dust mite was measured by the 
      Pharmacia Unicap 100 system. The results from the two groups were compared. 
      SETTING: Birmingham Children's Hospital. PARTICIPANTS: Children between the ages 
      of 3 and 10. Children with Down's syndrome, cleft lip and palate, ciliary 
      abnormalities, known immunodeficiencies and cardiac abnormalities were excluded. 
      MAIN OUTCOME MEASURES: Total IgE and RAST to house dust mite. A RAST of >0.35 was 
      taken to be positive. RESULTS: There was no statistical difference between the 
      control and study groups for the total IgE. Six children from both study and 
      control groups had a raised house dust mite RAST. There was no difference in the 
      levels between either group. CONCLUSIONS: Our findings indicate that there is no 
      direct relationship between OME and biochemical evidence of allergy, specifically 
      to house dust mite.
FAU - Coulson, C J
AU  - Coulson CJ
AD  - Department of ENT, Queen Elizabeth Hospital, Birmingham, UK. 
      chriscoulson@doctors.org.uk
FAU - Drake-Lee, A B
AU  - Drake-Lee AB
FAU - Plant, T
AU  - Plant T
FAU - Drayson, M T
AU  - Drayson MT
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Otolaryngol
JT  - Clinical otolaryngology : official journal of ENT-UK ; official journal of 
      Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
JID - 101247023
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Animals
MH  - Antibody Specificity
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*complications
MH  - Immunoglobulin E/*blood/immunology
MH  - Male
MH  - Otitis Media with Effusion/etiology/*immunology
MH  - Pyroglyphidae/*immunology
MH  - Radioallergosorbent Test
EDAT- 2006/04/20 09:00
MHDA- 2008/01/30 09:00
CRDT- 2006/04/20 09:00
PHST- 2006/04/20 09:00 [pubmed]
PHST- 2008/01/30 09:00 [medline]
PHST- 2006/04/20 09:00 [entrez]
AID - COA1154 [pii]
AID - 10.1111/j.1749-4486.2006.01154.x [doi]
PST - ppublish
SO  - Clin Otolaryngol. 2006 Apr;31(2):130-3. doi: 10.1111/j.1749-4486.2006.01154.x.