PMID- 16621107
OWN - NLM
STAT- MEDLINE
DCOM- 20070130
LR  - 20060904
IS  - 0168-8227 (Print)
IS  - 0168-8227 (Linking)
VI  - 74
IP  - 1
DP  - 2006 Oct
TI  - Association of APOE (Hha1) and ACE (I/D) gene polymorphisms with type 2 diabetes 
      mellitus in North West India.
PG  - 95-102
AB  - Familial and epidemiological studies have shown that genetic factors play a role 
      in the development and progression of type 2 diabetes mellitus (T2DM). Asian 
      Indians have shown an increasing prevalence of T2DM. Apolipoprotein E (APOE) and 
      Angiotensin-1 converting enzyme (ACE) I/D polymorphisms have been associated with 
      T2DM. This study examined the association of APOE and ACE genes with T2DM 
      patients of Punjab, India. APOE (HhaI) and ACE (I/D) genotypes analysed by 
      polymerase chain reaction were available from 90 patients and 97 random healthy 
      controls. All loci and populations are in Hardy-Weinberg equilibrium. There is no 
      significant association of APOE vis-a-vis T2DM, however APOE*4 allele frequency 
      is low in diabetics (3.9% and 8.8%). DD genotype and *D allele of ACE are 
      associated with T2DM (OR=1.90, p<0.05, and OR=1.58, p<0.05, respectively). 
      Recessive and multiplicative mode of inheritance for *D allele provided the 
      strongest support for the association. Height, weight and BMI did not reveal any 
      significant association with APO or ACE. DD-33 and ID-23 combinations (ACE-APOE) 
      showed higher odds of 2.01 and 2.14, respectively. ACE but not APOE polymorphism 
      is positively associated with T2DM in Indian population, however, the synergistic 
      effects of DD-33 and ID-23 are also evident.
FAU - Singh, Puneet Pal
AU  - Singh PP
AD  - Department of Human Biology, Punjabi University Patiala, India.
FAU - Naz, Isma
AU  - Naz I
FAU - Gilmour, Ashley
AU  - Gilmour A
FAU - Singh, Monica
AU  - Singh M
FAU - Mastana, Sarabjit
AU  - Mastana S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060418
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Apolipoproteins E)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apolipoproteins E/*genetics
MH  - Diabetes Mellitus, Type 2/blood/enzymology/*genetics
MH  - Genotype
MH  - Humans
MH  - India
MH  - Middle Aged
MH  - Peptidyl-Dipeptidase A/*genetics
MH  - *Polymorphism, Genetic
MH  - Reference Values
EDAT- 2006/04/20 09:00
MHDA- 2007/01/31 09:00
CRDT- 2006/04/20 09:00
PHST- 2005/08/15 00:00 [received]
PHST- 2006/03/09 00:00 [accepted]
PHST- 2006/04/20 09:00 [pubmed]
PHST- 2007/01/31 09:00 [medline]
PHST- 2006/04/20 09:00 [entrez]
AID - S0168-8227(06)00078-7 [pii]
AID - 10.1016/j.diabres.2006.03.013 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2006 Oct;74(1):95-102. doi: 
      10.1016/j.diabres.2006.03.013. Epub 2006 Apr 18.