PMID- 16621213
OWN - NLM
STAT- MEDLINE
DCOM- 20060711
LR  - 20131121
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 223
IP  - 1-2
DP  - 2006 Jun 1
TI  - Effect of subchronic exposure to malathion on glycogen phosphorylase and 
      hexokinase activities in rat liver using native PAGE.
PG  - 9-14
AB  - The aim of this study was the evaluation of the effects of a subchronic exposure 
      to malathion, an organophosphorus (OP) insecticide, on plasma glucose and hepatic 
      enzymes of glycogenolysis and glycolysis in rats in vivo. Malathion was 
      administered intragastrically by stomach tube in the amount of 1 ml corn oil 
      containing 100mg/kg body weight (BW) daily for 32 days. At the end of the 
      experiment, the liver was removed. The activities of glycogen phosphorylase (GP) 
      and hexokinase (HK) were analysed in the homogenate. The methodology employed was 
      a non-denaturing electrophoresis followed by activity-staining (native PAGE). 
      Malathion decrease GP activity by 50% and increase HK activity by 10%. In 
      addition, an hepatomegaly was recorded with a rise in the hepatic glycogen rate 
      in malathion-treated rats. Moreover, subchronic administration of malathion has 
      no effect on blood glucose concentration. The storage of glycogen in liver may be 
      due to a stimulation of insulin secretion after the inhibition of 
      acethylcholinesterase activity in pancreatic beta cells by malathion. These 
      findings were in favour of an activation of glycogen storage by malathion.
FAU - Rezg, Raja
AU  - Rezg R
AD  - Laboratoire de Physiologie des Agressions, Faculte des Sciences de Tunis, Tunis, 
      Tunisia.
FAU - Mornagui, Bessem
AU  - Mornagui B
FAU - El-Arbi, Mosbeh
AU  - El-Arbi M
FAU - Kamoun, Abdelaziz
AU  - Kamoun A
FAU - El-Fazaa, Saloua
AU  - El-Fazaa S
FAU - Gharbi, Najoua
AU  - Gharbi N
LA  - eng
PT  - Journal Article
DEP - 20060418
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Blood Glucose)
RN  - 0 (Insecticides)
RN  - 9005-79-2 (Glycogen)
RN  - EC 2.4.1.- (Glycogen Phosphorylase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - U5N7SU872W (Malathion)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Weight/drug effects
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Glycogen/*metabolism
MH  - Glycogen Phosphorylase/*metabolism
MH  - Hexokinase/*metabolism
MH  - Insecticides/*toxicity
MH  - Liver/*drug effects/enzymology/metabolism
MH  - Malathion/*toxicity
MH  - Male
MH  - Organ Size/drug effects
MH  - Rats
MH  - Rats, Wistar
EDAT- 2006/04/20 09:00
MHDA- 2006/07/13 09:00
CRDT- 2006/04/20 09:00
PHST- 2006/01/06 00:00 [received]
PHST- 2006/02/26 00:00 [revised]
PHST- 2006/02/27 00:00 [accepted]
PHST- 2006/04/20 09:00 [pubmed]
PHST- 2006/07/13 09:00 [medline]
PHST- 2006/04/20 09:00 [entrez]
AID - S0300-483X(06)00135-1 [pii]
AID - 10.1016/j.tox.2006.02.020 [doi]
PST - ppublish
SO  - Toxicology. 2006 Jun 1;223(1-2):9-14. doi: 10.1016/j.tox.2006.02.020. Epub 2006 
      Apr 18.