PMID- 16623839
OWN - NLM
STAT- MEDLINE
DCOM- 20060530
LR  - 20151119
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 23
IP  - 7
DP  - 2006 Apr
TI  - Nicotine exposure in vivo induces long-lasting enhancement of NMDA 
      receptor-mediated currents in the hippocampus.
PG  - 1819-28
AB  - The use of nicotine via cigarette smoking forms long-lasting memories that are 
      recalled in response to environmental cues associated with previous nicotine use. 
      However, the changes in brain memory systems that underlie these long-lasting 
      memories are not well understood. The N-methyl-D-aspartate receptor (NMDAR) is 
      critical for long-lasting modifications of synapses. Here we show that in vivo 
      nicotine exposure induces the enhancement of NR2B-containing NMDAR-mediated 
      currents in the hippocampus, a brain region associated with the formation of 
      memories. This nicotine effect is maintained during continued nicotine exposure 
      and is accompanied by increased tyrosine phosphorylation of NR2B. Furthermore, 
      long-term potentiation (LTP), which is considered to be a cellular substrate of 
      learning and memory, induced in nicotine-exposed hippocampi contains a protein 
      synthesis-independent long-lasting component. An NR2B-selective antagonist blocks 
      a long-lasting component of LTP, but not LTP. These results suggest that exposure 
      to nicotine provides conditions that promote the induction of long-lasting 
      modifications of synapses, which may be involved in the formation of memories 
      involving nicotine use.
FAU - Yamazaki, Yoshihiko
AU  - Yamazaki Y
AD  - Department of Neurobiology and Behavior, University of California Irvine, CA 
      92697-4550, USA.
FAU - Jia, Yousheng
AU  - Jia Y
FAU - Niu, Rong
AU  - Niu R
FAU - Sumikawa, Katumi
AU  - Sumikawa K
LA  - eng
GR  - DA14542/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Nicotinic Agonists)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 42HK56048U (Tyrosine)
RN  - 6M3C89ZY6R (Nicotine)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Hippocampus/*drug effects/physiology
MH  - Long-Term Potentiation
MH  - Long-Term Synaptic Depression
MH  - Nicotine/administration & dosage/*pharmacology
MH  - Nicotinic Agonists/administration & dosage/*pharmacology
MH  - Patch-Clamp Techniques
MH  - Phosphorylation
MH  - Protein-Tyrosine Kinases/physiology
MH  - Pyramidal Cells/drug effects/physiology
MH  - Rats
MH  - Receptors, AMPA/physiology
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/metabolism/*physiology
MH  - Synapses/drug effects/physiology
MH  - Tyrosine/metabolism
EDAT- 2006/04/21 09:00
MHDA- 2006/05/31 09:00
CRDT- 2006/04/21 09:00
PHST- 2006/04/21 09:00 [pubmed]
PHST- 2006/05/31 09:00 [medline]
PHST- 2006/04/21 09:00 [entrez]
AID - EJN4714 [pii]
AID - 10.1111/j.1460-9568.2006.04714.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2006 Apr;23(7):1819-28. doi: 10.1111/j.1460-9568.2006.04714.x.