PMID- 16624410 OWN - NLM STAT- MEDLINE DCOM- 20061204 LR - 20060703 IS - 0160-4120 (Print) IS - 0160-4120 (Linking) VI - 32 IP - 6 DP - 2006 Aug TI - Determination of endocrine disruptors in Kafue lechwe (Kobus leche kafuensis) samples from the Lochinvar National Park of Zambia. PG - 718-23 AB - Analysis of serum, whole blood and liver tissue samples from Kafue lechwe in the Lochinvar National Park of Zambia for suspected endocrine disrupting compounds revealed high concentrations for some of the compounds. 45 samples of serum, whole blood and liver tissue were extracted by liquid-liquid extraction followed by an analysis using Gas Chromatography-Electron Capture Detection (GC-ECD). The following endocrine disruptors were analyzed: deltamethrin, aldrin, endosulfan, dieldrin, pp-DDD, heptachlor, d-t-allethrin, pp-DDE, endrin and pp-DDT. For all the samples, dieldrin showed the highest concentration ranging from 1.7 to 44.4 microg/ml in serum and whole blood sample extracts and 0.10-5.1 microg/g wet weight in liver sample extracts. The most frequently detected was deltamethrin in 62% of the samples. Percent recoveries in spiked laboratory blanks ranged between 60% and 100% while calculated detection limits ranged from 0.004 to 0.21 microg/ml for all the endocrine disruptors evaluated. Where endocrine disruptors were detected, the concentrations of most of them far exceeded the maximum residue limits (MRLs) and the extraneous maximum residue limits (EMRLs) set by the Codex Alimentarius of the United Nations (UN), Food and Agricultural Organization (FAO). FAU - Sichilongo, Kwenga AU - Sichilongo K AD - University of Zambia, Department of Chemistry, P.O. Box 32379, Lusaka 10101, Zambia. ksichilo@natsci.unza.zm FAU - Torto, Nelson AU - Torto N LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20060419 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Endocrine Disruptors) RN - 0 (Environmental Pollutants) RN - 0 (Insecticides) SB - IM MH - Animals MH - Antelopes/*metabolism MH - Endocrine Disruptors/*analysis/blood MH - Environmental Monitoring MH - Environmental Pollutants/analysis/blood MH - Female MH - Insecticides/*analysis/blood MH - Liver/chemistry MH - Male MH - Zambia EDAT- 2006/04/21 09:00 MHDA- 2006/12/09 09:00 CRDT- 2006/04/21 09:00 PHST- 2005/09/27 00:00 [received] PHST- 2006/03/02 00:00 [revised] PHST- 2006/03/08 00:00 [accepted] PHST- 2006/04/21 09:00 [pubmed] PHST- 2006/12/09 09:00 [medline] PHST- 2006/04/21 09:00 [entrez] AID - S0160-4120(06)00038-9 [pii] AID - 10.1016/j.envint.2006.03.007 [doi] PST - ppublish SO - Environ Int. 2006 Aug;32(6):718-23. doi: 10.1016/j.envint.2006.03.007. Epub 2006 Apr 19.