PMID- 16624468
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20121115
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 30
IP  - 5
DP  - 2006 Jul
TI  - Ziprasidone-associated pedal edema in the treatment of schizophrenia.
PG  - 963-4
AB  - It has been reported that second generation of antipsychotic drugs may induce 
      pedal edema. The purpose of this case report is to demonstrate that the recently 
      marketed antipsychotic drug, ziprasidone induced pedal edema with an increased 
      plasma immunoglobulin E (IgE) level. A 51-year-old female schizophrenic patient 
      who developed severe pedal edema was treated with ziprasidone for 6 weeks. 
      Admission routine data that included biochemical, blood and urine analysis were 
      normal except for the plasma IgE level, which was significantly elevated. 
      Although the pedal edema subsided after discontinuation of ziprasidone and 
      administration of diuretics, the plasma IgE level remained high. This is the 
      first case report attempting to demonstrate the existence of ziprasidone-induced 
      pedal edema in the treatment of schizophrenia. In this case, the pedal edema was 
      associated with an IgE-related allergic reaction.
FAU - Ku, Hsiao-Lun
AU  - Ku HL
AD  - Department of Psychiatry, Taipei Veterans General Hospital, and National Yang 
      Ming University, Taipei, Taiwan.
FAU - Su, Tung-Ping
AU  - Su TP
FAU - Chou, Yuan-Hwa
AU  - Chou YH
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20060306
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Diuretics)
RN  - 0 (Piperazines)
RN  - 0 (Thiazoles)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 6UKA5VEJ6X (ziprasidone)
SB  - IM
MH  - Antipsychotic Agents/*adverse effects/*therapeutic use
MH  - Diuretics/therapeutic use
MH  - Drug Hypersensitivity/physiopathology
MH  - Edema/*chemically induced/pathology
MH  - Female
MH  - Foot Diseases/*chemically induced/pathology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Middle Aged
MH  - Piperazines/*adverse effects/*therapeutic use
MH  - Schizophrenia/*complications/*drug therapy
MH  - Thiazoles/*adverse effects/*therapeutic use
EDAT- 2006/04/21 09:00
MHDA- 2006/08/19 09:00
CRDT- 2006/04/21 09:00
PHST- 2006/01/30 00:00 [accepted]
PHST- 2006/04/21 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2006/04/21 09:00 [entrez]
AID - S0278-5846(06)00046-7 [pii]
AID - 10.1016/j.pnpbp.2006.01.020 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jul;30(5):963-4. doi: 
      10.1016/j.pnpbp.2006.01.020. Epub 2006 Mar 6.