PMID- 16624534
OWN - NLM
STAT- MEDLINE
DCOM- 20070306
LR  - 20191210
IS  - 0924-977X (Print)
IS  - 0924-977X (Linking)
VI  - 17
IP  - 1
DP  - 2007 Jan
TI  - GABA(A) receptors of hippocampal CA1 regions are involved in the acquisition and 
      expression of morphine-induced place preference.
PG  - 24-31
AB  - In the present study, the effects of bilateral intra-hippocampal CA1 (intra-CA1) 
      injections of GABA(A) receptor agonist and/or antagonist on the acquisition and 
      expression of morphine-induced place preference in male Wistar rats have been 
      investigated. The conditioning treatments with subcutaneous (s.c.) injections of 
      different doses of morphine (0.5-7.5 mg/kg) induced a conditioned place 
      preference (CPP) for the drug-associated place in a dose-dependent manner. 
      Intra-CA1 administration of the GABA(A) receptor agonist, muscimol (0.25, 0.5 and 
      1 microg/rat) significantly inhibited the morphine (5 mg/kg, s.c.)-induced CPP. 
      Intra-CA1 injections of different doses of the GABA(A) receptor antagonist, 
      bicuculline (0.25, 0.5 and 1 microg/rat), in combination with an ineffective dose 
      of morphine (0.5 mg/kg, s.c.) elicited a significant CPP. However, muscimol or 
      bicuculline by themselves did not elicit any effect on place conditioning. 
      Furthermore, the muscimol-induced inhibition of morphine response was reversed by 
      bicuculline (1 microg/rat, intra-CA1) administration. On the other hand, the 
      bilateral intra-CA1 injections of muscimol (0.25, 0.5 and 1 microg/rat) or 
      bicuculline (0.5, 1 and 2 microg/rat) significantly decreased the expression of 
      morphine-induced CPP. Intra-CA1 administration of different doses of muscimol or 
      bicuculline had no effect on locomotor activity in the testing phase. Our data 
      indicated that the GABA(A) receptors of the hippocampal CA1 regions may play an 
      important role in the acquisition and expression of morphine-induced place 
      preference.
FAU - Rezayof, Ameneh
AU  - Rezayof A
AD  - School of Biology, University College of Science, University of Tehran, Tehran, 
      Iran.
FAU - Razavi, Samira
AU  - Razavi S
FAU - Haeri-Rohani, Ali
AU  - Haeri-Rohani A
FAU - Rassouli, Yassaman
AU  - Rassouli Y
FAU - Zarrindast, Mohammad-Reza
AU  - Zarrindast MR
LA  - eng
PT  - Journal Article
DEP - 20060306
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (GABA Agonists)
RN  - 0 (GABA Antagonists)
RN  - 0 (Narcotics)
RN  - 0 (Receptors, GABA-A)
RN  - 2763-96-4 (Muscimol)
RN  - 76I7G6D29C (Morphine)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Bicuculline/pharmacology
MH  - Conditioning, Operant/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Functional Laterality
MH  - GABA Agonists/pharmacology
MH  - GABA Antagonists/pharmacology
MH  - Hippocampus/drug effects/*physiology
MH  - Male
MH  - Morphine/*administration & dosage
MH  - Motor Activity/drug effects
MH  - Muscimol/pharmacology
MH  - Narcotics/*administration & dosage
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, GABA-A/*physiology
MH  - Reinforcement, Psychology
EDAT- 2006/04/21 09:00
MHDA- 2007/03/07 09:00
CRDT- 2006/04/21 09:00
PHST- 2005/07/09 00:00 [received]
PHST- 2006/01/29 00:00 [revised]
PHST- 2006/02/14 00:00 [accepted]
PHST- 2006/04/21 09:00 [pubmed]
PHST- 2007/03/07 09:00 [medline]
PHST- 2006/04/21 09:00 [entrez]
AID - S0924-977X(06)00030-7 [pii]
AID - 10.1016/j.euroneuro.2006.02.003 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2007 Jan;17(1):24-31. doi: 
      10.1016/j.euroneuro.2006.02.003. Epub 2006 Mar 6.