PMID- 16624549
OWN - NLM
STAT- MEDLINE
DCOM- 20060728
LR  - 20220410
IS  - 0959-8049 (Print)
IS  - 0959-8049 (Linking)
VI  - 42
IP  - 8
DP  - 2006 May
TI  - International neuroblastoma pathology classification adds independent prognostic 
      information beyond the prognostic contribution of age.
PG  - 1113-9
AB  - Age has been used as a prognostic factor for patients with peripheral 
      neuroblastic tumours (pNTs). The latest analysis disclosed a cut-off around 18 
      months for the optimal prognostic distinction. The International Neuroblastoma 
      Pathology Classification (INPC) distinguishes favourable and unfavourable 
      histology based on the age-appropriate evaluation of histologic indicators (grade 
      of neuroblastic differentiation, mitosis-karyorrhexis index) in the categories of 
      neuroblastoma and ganglioneuroblastoma, nodular. This study showed that age 
      tested by using 3 different cut-offs (12, 18, 24 months) was prognostically 
      significant. INPC remained prognostically significant regardless of the age group 
      to which it was applied. Prognostic effects of age and histologic indicators were 
      independently significant, i.e., age had prognostic ability beyond that of 
      histologic indicators, and histologic indicators had prognostic ability beyond 
      that of age. Due to the fact that INPC incorporated age factor (18, 60 months) in 
      the system, it served better than age by itself for prognostic distinction of pNT 
      patients.
FAU - Sano, Hideki
AU  - Sano H
AD  - Department of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles, 
      and Keck School of Medicine, University of Southern California, 4650 Sunset Blvd. 
      M.S. #43, Los Angeles, CA 90027, United States.
FAU - Bonadio, Jeffrey
AU  - Bonadio J
FAU - Gerbing, Robert B
AU  - Gerbing RB
FAU - London, Wendy B
AU  - London WB
FAU - Matthay, Katherine K
AU  - Matthay KK
FAU - Lukens, John N
AU  - Lukens JN
FAU - Shimada, Hiroyuki
AU  - Shimada H
LA  - eng
GR  - CA13539/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060418
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
SB  - IM
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Disease-Free Survival
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Neuroblastoma/classification/*pathology
MH  - Peripheral Nervous System Neoplasms/classification/*pathology
MH  - Prognosis
EDAT- 2006/04/21 09:00
MHDA- 2006/07/29 09:00
CRDT- 2006/04/21 09:00
PHST- 2005/10/13 00:00 [received]
PHST- 2005/11/08 00:00 [accepted]
PHST- 2006/04/21 09:00 [pubmed]
PHST- 2006/07/29 09:00 [medline]
PHST- 2006/04/21 09:00 [entrez]
AID - S0959-8049(06)00177-8 [pii]
AID - 10.1016/j.ejca.2005.11.031 [doi]
PST - ppublish
SO  - Eur J Cancer. 2006 May;42(8):1113-9. doi: 10.1016/j.ejca.2005.11.031. Epub 2006 
      Apr 18.