PMID- 16624669
OWN - NLM
STAT- MEDLINE
DCOM- 20060608
LR  - 20131121
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 69
IP  - 4
DP  - 2006 Apr 28
TI  - Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine 
      (MDMA) on the subsequent stimulation of acetylcholine release in the rat 
      prefrontal cortex.
PG  - 382-7
AB  - The amphetamine analog 3,4-methylenedioxymethamphetamine (MDMA) is considered to 
      be selectively neurotoxic to serotonergic nerve terminals. Although the long term 
      effects of MDMA on serotonin (5-HT) terminals have been well studied, other 
      potential neurochemical consequences associated with MDMA-induced 5-HT depletion 
      have been less well investigated. In view of the cognitive impairments in human 
      MDMA abusers and the role of acetylcholine (ACh) in learning and memory, it was 
      of interest to determine the influence of a 5-HT depleting regimen of MDMA on 
      subsequent stimulation of ACh release in the prefrontal cortex (PFC). Male rats 
      received vehicle or MDMA (10 mg/kg, i.p. every 2 h for four injections) and 
      underwent in vivo microdialysis 7 days later to assess the subsequent drug- 
      (e.g., MDMA, 5-HT1A agonist) or stress- (e.g., tail pinch, presence of an 
      intruder rat) induced stimulation of ACh release. The increase in the 
      extracellular concentration of ACh in the PFC produced by MDMA (10 mg/kg, i.p.) 
      was significantly less in rats previously exposed to the neurotoxic regimen of 
      MDMA than that in control animals. In contrast, there was no difference in the 
      magnitude of the stimulation of cortical ACh release elicited by the 5-HT1A 
      agonist, 8-hydroxy-2-(di-n-propyl-amino)tetralin (8-OH-DPAT, 0.3mg/kg, s.c.), 
      tail pinch (30 min) or the presence of an intruder rat (40 min) between control 
      animals and animals previously exposed to a neurotoxic regimen of MDMA. These 
      results suggest that although MDMA-induced 5-HT depletion diminishes subsequent 
      MDMA-induced ACh release, there is little impact on cortical ACh release elicited 
      by the stress of pain or the novelty of an environmental intruder.
FAU - Nair, S G
AU  - Nair SG
AD  - College of Pharmacy, University of Cincinnati, 3223 Eden Av., Cincinnati, OH 
      45267, USA.
FAU - Gudelsky, G A
AU  - Gudelsky GA
LA  - eng
GR  - DA 07427/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060214
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Serotonin Agents)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 333DO1RDJY (Serotonin)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Acetylcholine/*metabolism
MH  - Animals
MH  - Male
MH  - Microdialysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Prefrontal Cortex/*drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - Serotonin Agents/*toxicity
MH  - Serotonin Receptor Agonists/pharmacology
MH  - Stress, Psychological/metabolism
EDAT- 2006/04/21 09:00
MHDA- 2006/06/09 09:00
CRDT- 2006/04/21 09:00
PHST- 2005/08/05 00:00 [received]
PHST- 2005/12/19 00:00 [revised]
PHST- 2006/01/23 00:00 [accepted]
PHST- 2006/04/21 09:00 [pubmed]
PHST- 2006/06/09 09:00 [medline]
PHST- 2006/04/21 09:00 [entrez]
AID - S0361-9230(06)00044-X [pii]
AID - 10.1016/j.brainresbull.2006.01.011 [doi]
PST - ppublish
SO  - Brain Res Bull. 2006 Apr 28;69(4):382-7. doi: 10.1016/j.brainresbull.2006.01.011. 
      Epub 2006 Feb 14.