PMID- 16624904
OWN - NLM
STAT- MEDLINE
DCOM- 20060908
LR  - 20211020
IS  - 0016-6731 (Print)
IS  - 0016-6731 (Linking)
VI  - 173
IP  - 2
DP  - 2006 Jun
TI  - Identification and classification of genes that act antagonistically to let-60 
      Ras signaling in Caenorhabditis elegans vulval development.
PG  - 709-26
AB  - The synthetic multivulva (synMuv) genes negatively regulate Ras-mediated vulval 
      induction in the nematode Caenorhabditis elegans. The synMuv genes define three 
      classes, A, B, and C, such that double mutants carrying mutations in genes of any 
      two classes are multivulva. The class B synMuv genes include lin-35, a homolog of 
      the retinoblastoma (Rb) tumor suppressor gene, as well as homologs of genes that 
      function with Rb in transcriptional regulation. We screened for additional synMuv 
      mutations using a strategy different from that of previous synMuv genetic 
      screens. Some of the mutations we recovered affect new synMuv genes. We present 
      criteria for assigning synMuv mutations into different genetic classes. We also 
      describe the molecular characterization of the class B synMuv gene lin-65.
FAU - Ceol, Craig J
AU  - Ceol CJ
AD  - Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute 
      of Technology, Cambridge, Massachusetts 02139, USA.
FAU - Stegmeier, Frank
AU  - Stegmeier F
FAU - Harrison, Melissa M
AU  - Harrison MM
FAU - Horvitz, H Robert
AU  - Horvitz HR
LA  - eng
SI  - GENBANK/AY818712
SI  - GENBANK/AY818713
GR  - R01 GM024663/GM/NIGMS NIH HHS/United States
GR  - R37 GM024663/GM/NIGMS NIH HHS/United States
GR  - GM24663/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060419
PL  - United States
TA  - Genetics
JT  - Genetics
JID - 0374636
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (DNA, Helminth)
RN  - 133135-08-7 (let-60 protein, C elegans)
RN  - EC 3.6.5.2 (ras Proteins)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Caenorhabditis elegans/*genetics/*growth & development/metabolism
MH  - Caenorhabditis elegans Proteins/*genetics/metabolism
MH  - Crosses, Genetic
MH  - DNA, Helminth/genetics
MH  - Female
MH  - *Genes, Helminth
MH  - Genetic Linkage
MH  - Heterozygote
MH  - Male
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Phenotype
MH  - Signal Transduction
MH  - Vulva/growth & development
MH  - ras Proteins/*genetics/metabolism
PMC - PMC1526536
EDAT- 2006/04/21 09:00
MHDA- 2006/09/09 09:00
PMCR- 2006/09/01
CRDT- 2006/04/21 09:00
PHST- 2006/04/21 09:00 [pubmed]
PHST- 2006/09/09 09:00 [medline]
PHST- 2006/04/21 09:00 [entrez]
PHST- 2006/09/01 00:00 [pmc-release]
AID - genetics.106.056465 [pii]
AID - gen1732709 [pii]
AID - 10.1534/genetics.106.056465 [doi]
PST - ppublish
SO  - Genetics. 2006 Jun;173(2):709-26. doi: 10.1534/genetics.106.056465. Epub 2006 Apr 
      19.