PMID- 16625848
OWN - NLM
STAT- MEDLINE
DCOM- 20060612
LR  - 20181201
IS  - 0391-4097 (Print)
IS  - 0391-4097 (Linking)
VI  - 28
IP  - 11 Suppl International
DP  - 2005
TI  - An overview of the epidemiology and genetics of acromegaly.
PG  - 67-9
AB  - Historical data indicate that pituitary tumors represent 10% of intracranial 
      tumors, while adenomas are noted in approximately 14-23% of normal subjects on 
      autopsy or magnetic resonance imaging (MRI). About 2.5% of these tumors stain 
      positive for GH in histopathologic studies. In contrast, the prevalence of 
      clinically diagnosed acromegaly is lower at 36-69 per million population. Ongoing 
      studies indicate that the actual prevalence of acromegaly in the community may be 
      higher than previous epidemiologic data suggest. Acromegaly can occur both 
      sporadically and in the setting of familial conditions, such as multiple 
      endocrine neoplasia type 1 (MEN1) and Carney complex (CNC). Isolated familial 
      somatotropinoma has been described and newer data suggest that acromegaly may 
      also occur in non-MEN1/CNC families in combination with other pituitary tumor 
      phenotypes.
FAU - Daly, A F
AU  - Daly AF
AD  - Department of Endocrinology, Domaine Universitaire du Sart Tilman, Liege, 
      Belgium.
FAU - Petrossians, P
AU  - Petrossians P
FAU - Beckers, A
AU  - Beckers A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Acromegaly/*epidemiology/*genetics
MH  - Adenoma/epidemiology/genetics
MH  - Female
MH  - Growth Hormone/metabolism
MH  - Humans
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/genetics
MH  - Pituitary Neoplasms/epidemiology/genetics
RF  - 24
EDAT- 2006/04/22 09:00
MHDA- 2006/06/13 09:00
CRDT- 2006/04/22 09:00
PHST- 2006/04/22 09:00 [pubmed]
PHST- 2006/06/13 09:00 [medline]
PHST- 2006/04/22 09:00 [entrez]
PST - ppublish
SO  - J Endocrinol Invest. 2005;28(11 Suppl International):67-9.