PMID- 16626574
OWN - NLM
STAT- MEDLINE
DCOM- 20090707
LR  - 20111017
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 34
IP  - 2
DP  - 2006 Feb
TI  - [Transplantation of autologous bone marrow mononuclear cells on patients with 
      idiopathic dilated cardiomyopathy: early results on effect and security].
PG  - 111-3
AB  - OBJECTIVE: The aim of this study is to identify short-term result of cell 
      transplantation in idiopathic dilated cardiomyopathy (IDC) patients who were 
      treated by intracoronary transplantation of autologous mononuclear bone marrow 
      cells (BMCs) in addition to standard therapy. METHODS: Based on given standard 
      therapy, eighteen patients with idiopathic dilated cardiomyopathy were enrolled 
      and divided into transplantation group and control group. The clinical 
      characteristics of two groups were comparable. Among these patients, 10 patients 
      were performed percutaneous coronary autologous BMCs transplantation. Blood 
      routine test, hepatic function, renal function, glucose, triglyceride (TG), 
      cholesterol, low density cholesterol (LDL), high density cholesterol (HDL), uric 
      acid (UA) and high sensitive C-reactive protein (hsCRP) were measured at the time 
      point of pre-operation and some time after transplantation. All patients were 
      monitored under ultrasonic cardiography, Holter, six-minute-walk test and 
      magnetic resonance imaging over a period of at least 6 months. Annual hospital 
      days were recorded during two-year follow-up. RESULTS: Blood routine test, 
      hepatic function, renal function, glucose, TG, cholesterol, LDL, HDL, UA and 
      hsCRP had no significant differences among 48 hours, 3 months and 6 months after 
      transplantation compared with control and pre-transplantation (P > 0.05). 
      Six-minute-walk distance elevated significantly six months after BMCs 
      transplantation compared with control and pre-transplantation [(494.3 +/- 62.8) m 
      vs (307.2 +/- 75.0) m, (321.5 +/- 63.7) m, P < 0.05]. Left ventricular ejection 
      fraction (LVEF) and the sizes of LVEDd had no significant changes compared with 
      that of control and pre-transplantation (P > 0.05). Myocardium lesion area 
      measured by (MRI) seemed decrease in transplantation group compared with that of 
      control and pre-operation [(4.96 +/- 0.47) cm(2) vs (5.12 +/- 0.54) cm(2), (5.02 
      +/- 0.39) cm(2), P > 0.05], but there was no significance. None of proarrhythmias 
      and side effects had been observed around transplantation and 2 years follow-up. 
      There was no significant difference in survival between two groups in 2 years 
      follow-up. Interestingly, annual hospital day in BMCs transplantation patients 
      was significantly shorter than that in control group [(30.2 +/- 11.2) d vs (43.6 
      +/- 9.8) d, P < 0.05]. CONCLUSIONS: Autologous bone marrow mononuclear cells 
      transplantation can prolong six-minute-walk, decrease re-hospitalization rate, 
      elevate exercise ability and help to improve cardiac function in patients with 
      IDC. In addition, it was demonstrated that cell transplantation is safe.
FAU - Huang, Rong-chong
AU  - Huang RC
AD  - Centre of Stem Cell and Histological Project, Shanghai Institute of 
      Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai 200032, 
      China.
FAU - Yao, Kang
AU  - Yao K
FAU - Li, Yan-lin
AU  - Li YL
FAU - Zhang, Yi-qi
AU  - Zhang YQ
FAU - Xu, Shi-kun
AU  - Xu SK
FAU - Shi, Hong-yu
AU  - Shi HY
FAU - Pan, Cui-zhen
AU  - Pan CZ
FAU - Yang, Shan
AU  - Yang S
FAU - Zhang, Shao-heng
AU  - Zhang SH
FAU - Ge, Lei
AU  - Ge L
FAU - Niu, Yu-hong
AU  - Niu YH
FAU - Zhang, Feng
AU  - Zhang F
FAU - Qian, Ju-ying
AU  - Qian JY
FAU - Zou, Yun-zeng
AU  - Zou YZ
FAU - Ge, Jun-Bo
AU  - Ge JB
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
SB  - IM
MH  - *Bone Marrow Transplantation
MH  - Cardiomyopathy, Dilated/surgery/*therapy
MH  - Humans
MH  - Transplantation, Autologous
MH  - Treatment Outcome
EDAT- 2006/04/22 09:00
MHDA- 2009/07/08 09:00
CRDT- 2006/04/22 09:00
PHST- 2006/04/22 09:00 [pubmed]
PHST- 2009/07/08 09:00 [medline]
PHST- 2006/04/22 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2006 Feb;34(2):111-3.